本文關鍵詞：慢性乙型肝炎證候虛實分類與外周血淋巴細胞亞群的關系　出處：《中國中醫(yī)基礎醫(yī)學雜志》2017年05期 　論文類型：期刊論文

  更多相關文章： 慢性乙型肝炎 免疫狀態(tài) 中醫(yī)虛實分類 T淋巴細胞 B淋巴細胞 NK細胞

【摘要】：目的:了解慢性乙型肝炎(CHB)患者中醫(yī)證候虛實分類與外周血淋巴細胞亞群之間的關系。方法:將CHB患者進行證候虛證、實證及虛實夾雜證分類,并檢測其外周血T、B細胞及自然殺傷(NK)細胞亞群,并對其3個證型組的指標進行分析。結果:CHB虛證、實證及虛實夾雜3個組的CD4~+T細胞百分比均較對照組低;CD8~+T細胞百分比由高至低依次為實證組、虛實夾雜證組、對照組、虛證組,實證組CD4~+/CD8~+比值顯著低于虛證組或?qū)φ战M,3個組的B細胞百分比均高于對照組,NK細胞百分比低于對照組。結論:CHB存在著免疫調(diào)節(jié)紊亂,證候虛實分類與外周血淋巴細胞亞群之間存在一定的相關性,中醫(yī)虛實證辨證結合免疫功能檢測具有一定的臨床意義。
[Abstract]:Objective: to understand the relationship between TCM syndrome deficiency and peripheral blood lymphocyte subsets in patients with chronic hepatitis B. methods: CHB patients were divided into syndromes deficiency syndrome, positive syndrome and deficiency and excess syndrome. The subsets of T B cells and NK cells in peripheral blood were detected, and the indexes of the three syndromes were analyzed. The percentages of CD4T cells in the three groups were lower than those in the control group. The percentage of CD8 ~ T cells was significantly lower in the group of deficiency syndrome than that in the group of deficiency syndrome or control group, and the ratio of CD4 ~ / CD8 ~ ~ in the group of deficiency syndrome and deficiency syndrome was significantly lower than that in the group of deficiency syndrome or control group in the order of CD8T cell percentage from high to low. The percentage of B cells in the three groups was higher than that in the control group, and the percentage of NK cells in the three groups was lower than that in the control group. There is a certain correlation between the classification of deficiency and deficiency of syndrome and lymphocyte subsets in peripheral blood. It is of certain clinical significance to detect the deficiency and deficiency of syndrome combined with immune function in TCM.
【作者單位】： 桂林醫(yī)學院附屬醫(yī)院;
【基金】：國家自然科學基金資助項目(81260602)-HBV感染不同免疫狀態(tài)證候要素與外周血淋巴細胞亞群的關系
【分類號】：R259
【正文快照】： 我國一般人群乙型肝炎病毒(hepatitis B virus,HBV)流行率為7.18%,估計約9300萬人為慢性HBV感染,其中慢性乙型肝炎(chronic hepatitis BCHB)患者約2000萬例[1]。中西醫(yī)結合防治CHB是我國獨特的方法,中醫(yī)藥對人體免疫功能的影響是大多數(shù)中藥抗病毒的主要機制之一,其治療優(yōu)勢在

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