本文關(guān)鍵詞：柴胡疏肝明目丸治療肝郁腎虛兼血瘀型慢性前葡萄膜炎的臨床研究　出處：《河南中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 慢性前葡萄膜炎 柴胡疏肝明目丸 醋酸潑尼松片 肝郁腎虛 血瘀

【摘要】：目的:觀察和評(píng)價(jià)柴胡疏肝明目丸治療肝郁腎虛兼血瘀型慢性前葡萄膜炎的臨床療效。方法:將60例(86眼)肝郁腎虛兼血瘀型的慢性前葡萄膜炎患者,按照隨機(jī)數(shù)字表法分為治療組和對(duì)照組;治療組30例(44眼)口服柴胡疏肝明目丸,對(duì)照組30例(42眼)醋酸潑尼松片按需口服,并給予維D鈣咀嚼片、枸櫞酸鉀顆粒和奧美拉唑腸溶片輔助治療。兩組患者均同時(shí)給予硫酸阿托品眼用凝膠和妥布霉素地塞米松滴眼液點(diǎn)眼局部治療。兩組均以30天為1個(gè)療程,治療3個(gè)療程90天后觀察兩組患者的視力、眼部體征及中醫(yī)癥狀積分的變化,進(jìn)行臨床療效評(píng)價(jià)。并且所有的患者在治療結(jié)束后隨診6個(gè)月觀察復(fù)發(fā)率。結(jié)果:(1)兩組患者綜合臨床療效比較:治療組44眼,治愈10眼,有效18眼,顯效12眼,無效4眼,總有效率為90.9%;對(duì)照組42眼,治愈3眼,有效12眼,顯效19眼,無效8眼,總有效率為80.95%,經(jīng)過統(tǒng)計(jì)軟件分析處理發(fā)現(xiàn)有顯著性差異(P0.05),說明治療組的綜合臨床療效優(yōu)于對(duì)照組。(2)兩組患者視力比較:治療前視力比較無明顯差異性(P0.05),具有可比性;治療后與治療前相比,兩組均有顯著性差異(P0.05),說明兩種治療方法都能改善患者視力,并且治療組提高明顯。(3)兩組患者眼部體征積分比較:治療前經(jīng)統(tǒng)計(jì)分析比較無明顯差異性(P0.05),具有可比性;治療后與治療前相比,兩組均有顯著性差異(P0.05),表明兩種治療方案都能改善眼部體征,且治療組明顯優(yōu)于對(duì)照組(4)兩組中醫(yī)證候療效比較:治療組總有效率(86.67%)高于對(duì)照組(66.67%),經(jīng)統(tǒng)計(jì)學(xué)分析(P0.05)有顯著性差異,表示治療組的中醫(yī)證候療效優(yōu)于對(duì)照組。(5)復(fù)發(fā)率比較:隨訪6個(gè)月,治療組復(fù)發(fā)6例8眼,復(fù)發(fā)率為18.18%,對(duì)照組復(fù)發(fā)26例33眼,復(fù)發(fā)率為78.57%,經(jīng)統(tǒng)計(jì)學(xué)分析P0.05,差異有顯著性,說明柴胡疏肝明目丸能降低復(fù)發(fā)率。結(jié)論:柴胡疏肝明目丸治療肝郁腎虛兼血瘀型的慢性前葡萄膜炎患者的臨床療效確切,能提高患者視力,減輕眼部不適癥狀,改善患者全身癥狀,可有效降低復(fù)發(fā)率。
[Abstract]:Objective: to observe and evaluate the clinical effect of Chaihu Shugan Mingmu pills on chronic anterior uveitis with liver stagnation and kidney deficiency combined with blood stasis. Methods: 60 cases (86 eyes) of chronic anterior uveitis with liver stagnation and kidney deficiency and blood stasis were treated. According to the method of random digital table, they were divided into treatment group and control group. The treatment group (30 cases, 44 eyes) took Chaihu Shugan Mingmu pills, the control group, 30 cases, 42 eyes), prednisone acetate tablets were given orally as needed, and were given vitamin D calcium chewable tablets. Both groups were treated with atropine sulfate eye gel and tobramycin dexamethasone eye drops. Both groups were treated with 30 days as a course of treatment. After three courses of treatment for 90 days, the changes of visual acuity, ocular signs and TCM symptom scores were observed in the two groups. All the patients were followed up for 6 months to observe the recurrence rate. Results the comprehensive clinical efficacy of the two groups was compared: 44 eyes in the treatment group, 10 eyes were cured. 18 eyes were effective, 12 eyes were effective, 4 eyes were ineffective, the total effective rate was 90.9%. 42 eyes of the control group were cured, 3 eyes were cured, 12 eyes were effective, 19 eyes were effective, 8 eyes were ineffective, the total effective rate was 80.955.The statistical software analysis showed that there was significant difference (P 0.05). The comprehensive clinical curative effect of the treatment group is better than that of the control group. (2) the visual acuity of the two groups is better than that of the control group: there is no significant difference in the visual acuity before treatment and the comparison is comparable; There was significant difference between the two groups after treatment and before treatment, indicating that the two treatment methods can improve the visual acuity of the patients. The scores of eye signs in the treatment group were improved significantly. (3) the scores of eye signs in the two groups were compared: there was no significant difference between the two groups before treatment and there was no significant difference (P 0.05), which was comparable; Compared with before and after treatment, there was significant difference between the two groups (P 0.05), indicating that the two treatments can improve the ocular signs. And the treatment group is significantly better than the control group (4) the two groups of TCM syndromes comparison: the total effective rate of the treatment group (86.67) is higher than the control group (66.67)). Statistical analysis showed that the curative effect of TCM syndrome in the treatment group was better than that in the control group (P 0.05). The recurrence rate of the treatment group was higher than that of the control group (P 0.05): 6 cases of 8 eyes in the treatment group were followed up for 6 months. The recurrence rate was 18.18% and the recurrence rate was 78.57 in 26 cases (33 eyes) in the control group. The difference was statistically significant (P0.05). Conclusion: Chaihu Shugan Mingmu pills is effective in the treatment of chronic anterior uveitis with liver depression and kidney deficiency and blood stasis, and can improve the visual acuity of the patients. Reducing ocular discomfort and improving patients' systemic symptoms can effectively reduce the recurrence rate.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R276.7

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