本文關鍵詞：撳針聯(lián)合氯雷他定治療兒童持續(xù)性過敏性鼻炎的臨床研究　出處：《成都中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

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【摘要】：目的：運用撳針聯(lián)合氯雷他定治療兒童持續(xù)性過敏性鼻炎(Persistent Allergic Rhinitis,PAR),觀察評估撳針聯(lián)合氯雷他定治療兒童PAR的有效性和安全性。方法：將75例PAR合格受試者,按2：2：1隨機分成三組：治療組(撳針加藥物組)30例,對照組Ⅰ(撳針組)30例,對照組Ⅱ(假針加藥物組)15例。治療組取印堂、雙迎香、雙足三里和雙肺俞,將撳針貼于上述穴位,一周兩次；并按患者年齡及體重服用相應劑量的氯雷他定片,每日一次,共服用三周。對照組Ⅰ針刺選穴、操作同治療組,不用藥物。對照組Ⅱ針刺使用定制的無針芯假針,余同治療組。治療前后采用癥狀量化評分表、癥狀視覺模擬量表(VAS)及鼻結膜炎相關生活質(zhì)量評分表(RQLQ)進行評估,觀察外周血清嗜酸性粒細胞百分比(EOSR)變化情況,于治療結束3周后隨訪復發(fā)情況。結果：(1)療效比較：治療后,治療組總有效率92.31%,對照組Ⅰ總有效率90.00%,對照組Ⅱ總有效率71.43%；治療組與對照組Ⅰ比較差異無統(tǒng)計學意義(P0.05),與對照組Ⅱ比較差異有統(tǒng)計學意義(P0.05)。(2)癥狀與生活質(zhì)量改善比較：組內(nèi)比較：三組治療前后的癥狀量化評分、VAS評分及RQLQ評分組內(nèi)比較,差異均有統(tǒng)計學意義(P0.05)；組間比較：治療后,在改善癥狀量化評分和RQLQ評分方面,治療組優(yōu)于對照組Ⅱ(P0.05),與對照組Ⅰ比較差異無統(tǒng)計學意義(P0.05)；治療后,治療組與兩個對照組的VAS評分差異均無統(tǒng)計學意義(P0.05)。(3)外周血清EOSR比較：三組治療前后的外周血清EOSR組內(nèi)比較差異有統(tǒng)計學意義(P0.05)；治療后,治療組與兩個對照組組間比較差異無統(tǒng)計學意義(P0.05)。(4)復發(fā)率比較：治療結束3周后進行隨訪,治療組與兩個對照組組間復發(fā)率比較,差異均無統(tǒng)計學意義(P0.05)。結論：(1)撳針加氯雷他定、撳針治療兒童PAR安全、有效。(2)撳針加藥物組在療效、降低癥狀量化評分及改善生活質(zhì)量方面優(yōu)于假針加藥物組。(3)撳針加藥物組與撳針組和假針加藥物組在緩解患者癥狀主觀感受、降低外周血EOSR和防止病情復發(fā)方面無顯著性差異。
[Abstract]:Objective: to use the needle combined with loratadine in treatment of children with persistent allergic rhinitis (Persistent Allergic, Rhinitis, PAR), to evaluate the efficacy and safety of needle combined with loratadine in the treatment of children with PAR. Methods: 75 cases of PAR qualified subjects, divided into three groups randomly: treatment group (by 2:2:1 needle plus drug group) 30 cases, control group I (needle group) 30 cases, control group II (sham acupuncture plus medication group of 15 cases). The treatment group, Yintang, double li20, double double Zusanli and Feishu, will press needle affixed to the above points, two times a week; and taking the corresponding dose of Loratadine Tablets according to the age and weight of patients, once a day, taking a total of three weeks. The control group I selected acupuncture points and operated the same treatment group without drugs. In the control group, the needling needle without needle core was used in the control group, and the treatment group was the same as the treatment group. Before and after treatment, symptom Quantification Scale, symptom visual analogue scale (VAS) and nasal conjunctivitis related quality of life scale (RQLQ) were used to evaluate the changes of peripheral blood eosinophil percentage (EOSR). After 3 weeks of treatment, the recurrence rate was observed. Results: (1) curative effect comparison: after treatment, the total effective rate of the treatment group was 92.31%, the total effective rate of the control group was 90%, the total effective rate of the control group was 71.43%, the difference between the treatment group and the control group was not statistically significant (P0.05), and the difference between the treatment group and the control group was statistically significant (P0.05). (2) comparison of symptoms and quality of life: group comparison: three groups before and after treatment of the symptom score and VAS score and RQLQ score in comparison, the differences were statistically significant (P0.05); group comparison: after treatment, in improving symptoms score and RQLQ score, the treatment group than the control group (II P0.05), and the control group had no significant difference (P0.05); after treatment, VAS score between the treatment group and two in the control group had no statistical significance (P0.05). (3) peripheral serum EOSR: there was a significant difference between the three groups before and after treatment in the EOSR group (P0.05). After treatment, there was no significant difference between the treatment group and the two control groups (P0.05). (4) the recurrence rate was compared: after 3 weeks of treatment, the recurrence rate was compared between the treatment group and the two control groups, the difference was not statistically significant (P0.05). Conclusion: (1) the acupuncture plus loratadine, needle is safe and effective in treatment of children with PAR. (2) the acupuncture plus medication group reduced symptoms score and improve the quality of life is better than sham acupuncture plus medication group in curative effect. (3) the acupuncture plus drug group and the acupuncture group and sham acupuncture plus medication group in relieving the symptoms of subjective feeling, reduce the peripheral blood EOSR and prevent the recurrence of the disease had no significant difference.
【學位授予單位】：成都中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R276.1

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