天堂国产午夜亚洲专区-少妇人妻综合久久蜜臀-国产成人户外露出视频在线-国产91传媒一区二区三区

當(dāng)前位置:主頁(yè) > 醫(yī)學(xué)論文 > 腫瘤論文 >

FOXM1在肺腺癌中的表達(dá)及與一線化療療效的關(guān)系

發(fā)布時(shí)間:2019-07-04 20:40
【摘要】:目的:肺癌是世界范圍內(nèi)致死率最高的腫瘤之一,叉頭框轉(zhuǎn)錄因子M1(FOXM1)是調(diào)控細(xì)胞周期的轉(zhuǎn)錄因子,參與細(xì)胞增殖、分化的調(diào)控過(guò)程,同時(shí)還可介導(dǎo)細(xì)胞DN A的損傷修復(fù)和細(xì)胞凋亡過(guò)程。FOXM1表達(dá)上調(diào)與多種惡性腫瘤的發(fā)生、發(fā)展及預(yù)后密切相關(guān)。最新相關(guān)研究提示FOXM1可能與腫瘤藥物耐藥存在密切關(guān)系。本研究探討非小細(xì)胞肺腺癌中叉頭框轉(zhuǎn)錄因子M1(FOXM1)的表達(dá)水平及其與臨床病理因素、一線化療無(wú)進(jìn)展生存期的關(guān)系,為FOXM1的表達(dá)與肺癌的治療預(yù)后提供新的理論依據(jù)。方法:收集新疆醫(yī)科大學(xué)附屬腫瘤醫(yī)院2012年~2015年期間非小細(xì)胞肺腺癌患者病理組織標(biāo)本77例,運(yùn)用免疫組化法檢測(cè)腫瘤組織中的FOXM1表達(dá)水平,并結(jié)合臨床病理特征及一線治療無(wú)進(jìn)展生存時(shí)間進(jìn)行分析。結(jié)果:FOXM1的表達(dá)水平與腫瘤細(xì)胞的分化間存在相關(guān)性(P=0.02)。FOXM1表達(dá)水平與一線化療治療無(wú)進(jìn)展生存時(shí)間及維持治療時(shí)間具有相關(guān)性(P=0.001,P=0.003),FOXM1表達(dá)陽(yáng)性患者的一線化療治療無(wú)進(jìn)展生存時(shí)間要低于FOXM1表達(dá)陰性患者;結(jié)果顯示FOXM1的陽(yáng)性表達(dá)、吸煙及性別是影響預(yù)后的獨(dú)立因素(P0.05)。結(jié)論:FO XM1表達(dá)水平與非小細(xì)胞肺腺癌一線治療無(wú)進(jìn)展生存時(shí)間密切相關(guān),提示FOXM1表達(dá)水平與化療治療預(yù)后呈負(fù)相關(guān)。FOXM1陽(yáng)性表達(dá)、吸煙及年齡這些因素可以作為NSCLC一線化療治療預(yù)后的獨(dú)立預(yù)測(cè)指標(biāo)
[Abstract]:Aim: lung cancer is one of the deadliest tumors in the world. Forked frame transcription factor M1 (FOXM1) is a transcription factor regulating cell cycle, which is involved in the regulation of cell proliferation and differentiation, and can also mediate the repair of cell DN A injury and apoptosis. The up-regulation of FOXM1 expression is closely related to the occurrence, development and prognosis of many kinds of malignant tumors. Recent studies suggest that FOXM1 may be closely related to tumor drug resistance. The purpose of this study was to investigate the expression of forked frame transcription factor M1 (FOXM1) in non-small cell lung adenocarcinoma and its relationship with clinicopathological factors and progression-free survival time of first-line chemotherapy, so as to provide a new theoretical basis for the expression of FOXM1 and the treatment and prognosis of lung cancer. Methods: the pathological specimens of 77 patients with non-small cell lung cancer from 2012 to 2015 were collected. The expression of FOXM1 in tumor tissues was detected by immunohistochemistry, and the clinicopathological features and the survival time of first-line treatment were analyzed. Results: there was a correlation between the expression level of FOXM1 and the differentiation of tumor cells (P 鈮,

本文編號(hào):2510217

資料下載
論文發(fā)表

本文鏈接:http://sikaile.net/yixuelunwen/zlx/2510217.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶(hù)edb5f***提供,本站僅收錄摘要或目錄,作者需要?jiǎng)h除請(qǐng)E-mail郵箱bigeng88@qq.com
日韩av亚洲一区二区三区| 欧美字幕一区二区三区| 亚洲国产四季欧美一区| 99久久国产综合精品二区| 一二区不卡不卡在线观看| 丰满人妻熟妇乱又乱精品古代 | 好吊色欧美一区二区三区顽频| 亚洲高清亚洲欧美一区二区| 久久99这里只精品热在线| 婷婷伊人综合中文字幕| 国产一区欧美午夜福利| 色婷婷中文字幕在线视频| 精品日韩国产高清毛片| 老司机亚洲精品一区二区| 亚洲国产另类久久精品| 欧美精品激情视频一区| 丝袜人妻夜夜爽一区二区三区| 老司机精品一区二区三区| 麻豆精品视频一二三区| 一区二区三区在线不卡免费| 又黄又硬又爽又色的视频| 日韩欧美三级视频在线| 真实偷拍一区二区免费视频| 欧美国产在线观看精品| 欧美日韩国产二三四区| 国产精品一区二区三区欧美| 亚洲另类欧美综合日韩精品| 久久偷拍视频免费观看| 亚洲综合香蕉在线视频| 九九热精彩视频在线播放| 精品国产亚洲av久一区二区三区| 欧美自拍系列精品在线| 亚洲综合精品天堂夜夜| 日本欧美视频在线观看免费| 国产精品欧美一区两区| 日韩成人h视频在线观看| 精品熟女少妇一区二区三区 | 亚洲国产av国产av| 高清不卡一卡二卡区在线| 色婷婷在线精品国自产拍| 91欧美亚洲视频在线|