【摘要】：目的:探討地塞米松在有效緩解肺癌骨轉(zhuǎn)移患者姑息放療導(dǎo)致的疼痛加重及其安全性。方法:選取山東大學(xué)附屬千佛山醫(yī)院2011年1月至2016年4月收治的103例肺癌骨轉(zhuǎn)移患者隨機(jī)分為地塞米松(觀察組)和安慰劑(對(duì)照組)治療,其中觀察組51例,對(duì)照組52例,分別于放療后給予地塞米松(5 mg,iv)/安慰劑(生理鹽水1 m L,iv)治療,比較兩組患者放療后疼痛情況。結(jié)果:觀察組的51例患者中13例(25%)發(fā)生疼痛加重;對(duì)照組的52例患者中20例(38%)發(fā)生疼痛加重(P=0.03)。結(jié)論:地塞米松可減少肺癌骨轉(zhuǎn)移放療引起的疼痛加重,該結(jié)論仍需進(jìn)一步的研究證實(shí)。
[Abstract]:Objective: to investigate the safety of dexamethasone in relieving pain aggravation caused by palliative radiotherapy in patients with bone metastasis of lung cancer. Methods: from January 2011 to April 2016, 103 patients with bone metastasis of lung cancer were randomly divided into dexamethasone (observation group) and placebo (control group). 51 patients in the observation group and 52 patients in the control group were treated with dexamethasone (5 mg,iv) / placebo (saline 1 mL, iv). The pain after radiotherapy was compared between the two groups. Results: pain aggravation occurred in 13 (25%) of 51 patients in the observation group and 20 (38%) in the control group (P 鈮，

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