【摘要】：目的:觀察紫杉醇聯(lián)合順鉑、氟尿嘧啶經(jīng)留置肝動脈導管給藥用于胃癌肝轉移的療效和安全性。方法:56例胃癌肝轉移患者隨機分為對照組(28例)和觀察組(28例)。對照組患者給予紫杉醇注射液135 mg/m~2,d_1+順鉑注射液75 mg/m~2,d_1+氟尿嘧啶注射液750 mg/m~2,d_(1-5),均經(jīng)中心靜脈泵給藥。觀察組患者給予紫杉醇注射液135 mg/m~2,d_1+順鉑注射液75 mg/m~2,d_1+氟尿嘧啶注射液750 mg/m~2,d_(1-5),均經(jīng)留置肝動脈導管給藥。兩組均以3~4周為1個周期,最多治療8個周期。兩組患者治療期間均靜脈滴注異甘草酸鎂注射液200 mg/d保肝治療。觀察兩組患者的臨床療效,治療前后血清癌胚抗原(CEA)、丙氨酸轉氨酶(ALT)、天冬氨酸轉氨酶(AST)水平及不良反應發(fā)生情況。結果:觀察組患者近期總有效率顯著高于對照組,差異有統(tǒng)計學意義(P0.01)。治療前,兩組患者CEA、ALT、AST水平比較,差異均無統(tǒng)計學意義(P0.05)。治療后,兩組患者CEA、ALT、AST水平均顯著高于同組治療前,且觀察組ALT、AST水平顯著高于對照組,但觀察組CEA水平顯著低于對照組,差異均有統(tǒng)計學意義(P0.05)。觀察組患者骨髓抑制、惡心嘔吐、發(fā)熱發(fā)生率均顯著低于對照組,差異均有統(tǒng)計學意義(P0.05)。結論:紫杉醇聯(lián)合順鉑、氟尿嘧啶經(jīng)留置肝動脈導管給藥用于胃癌肝轉移的療效較好,但存在肝功能損傷的現(xiàn)象。
[Abstract]:Objective: to observe the efficacy and safety of paclitaxel combined with DDP and Fluorouracil in the treatment of liver metastasis of gastric cancer. Methods: 56 patients with liver metastasis of gastric cancer were randomly divided into control group (28 cases) and observation group (28 cases). The patients in the control group were given paclitaxel injection 135 mg/m~2,d_1 DDP injection 75 mg/m~2,d_1 Fluorouracil injection 750 mg/m~2,d_ (1 鈮，

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