發(fā)布時間：2019-04-09 18:53

【摘要】：目的：評價柴苓杉貝湯聯(lián)合RCHOP方案治療氣郁痰結型NHL(非霍奇金淋巴瘤)的臨床療效及安全性。方法：用隨機數字法把符合入組標準的72例患者分為中藥加化療組(A組)和化療組(B組),各36例。兩組均接受了2周期的RCHOP方案的化療,其中A組于RCHOP方案化療開始同時口服中藥柴苓杉貝湯,150m1/次,日兩次(早晚)。觀察治療后骨髓抑制情況；外周血象(WBC, NEUT, PLT, Hb)變化情況；中醫(yī)臨床癥狀及生存質量的變化情況；肝腎功、心電異常發(fā)生情況。結果：1療效評價：骨髓抑制發(fā)生率A組為68.57%,B組為94.29%,A組較B組低,差異有統(tǒng)計學意義(P0.05)。A組與B組骨髓抑制分度比較,差異有統(tǒng)計學意義(P0.05)。與B組相比,A組治療后血象降低幅度小,差異有統(tǒng)計學意義(P0.05)。中醫(yī)癥狀改善有效率A組為65.71%,B組為8.57%,A組高于B組,差異有統(tǒng)計學意義(P0.05)。A組與B組中醫(yī)癥狀改善分度比較,差異有統(tǒng)計學意義(P0.05)。與B組相比,A組治療后中醫(yī)癥狀總積分和單個中醫(yī)癥狀積分下降幅度均較大,差異有統(tǒng)計學意義(P0.05)。與B組相比,A組治療后KPS評分提高幅度較大,差異有統(tǒng)計學意義(P0.05)。2肝腎功和心電圖異常發(fā)生評價：腎功正常；肝功異常情況對比(P0.05),差異無統(tǒng)計學意義,心電異常情況對比(P0.05),差異無統(tǒng)計學意義。結論：1.柴苓杉貝湯可以降低化療骨髓抑制發(fā)生率和改善骨髓抑制程度。2.柴苓杉貝湯可以改善血象降低情況。3.柴苓杉貝湯可以改善中醫(yī)臨床癥狀和改善患者生存質量。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of Chailing Shanbei decoction combined with RCHOP regimen in the treatment of NHL (non-Hodgkin's lymphoma) with qi depression and phlegm. Methods: 72 patients were randomly divided into two groups: group A (n = 36) and group B (n = 36), who were treated with Chinese medicine plus chemotherapy (group A) and chemotherapy group (group B, n = 36). Two cycles of RCHOP chemotherapy were given to both groups, in which group A took Chailing Shanbei decoction orally at the beginning of RCHOP regimen, 150m1/ twice a day (sooner or later). The changes of myelosuppression, peripheral blood (WBC, NEUT, PLT, Hb), clinical symptoms and quality of life of traditional Chinese medicine, liver and kidney function and abnormal ECG were observed after treatment. Results: 1 Evaluation of curative effect: the incidence of myelosuppression was 68.57% in group A and 94.29% in group B, which was significantly lower in group A than in group B (P0.05:). A group and B group). The difference was statistically significant (P0.05). Compared with group B, the hemogram of group A decreased slightly after treatment, the difference was statistically significant (P0.05). The effective rate of TCM symptom improvement in group A was 65.71%, group B was 8.57%, group A was higher than group B, the difference was statistically significant (P0.05). A group and B group, the difference was statistically significant (P0.05). Compared with group B, the total score of TCM symptom and the score of single symptom decreased significantly in group A after treatment, the difference was statistically significant (P0.05). Compared with group B, the scores of KPS in group A increased significantly after treatment (P0.05). (2) Evaluation of abnormal liver and kidney function and ECG: normal renal function; Liver function abnormality situation contrast (P0.05), the difference is not statistically significant, the ECG abnormal situation contrast (P0.05), the difference is not statistically significant. Conclusion: 1. Chailing Shanbei decoction can reduce the incidence of chemotherapy myelosuppression and improve the degree of myelosuppression. 2. Chailing shanbei decoction can improve the decrease of hemogram. 3. Chailing Shanbei decoction can improve the clinical symptoms of traditional Chinese medicine and improve the quality of life of patients.
【學位授予單位】：黑龍江中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R733.1

【相似文獻】

相關期刊論文 前10條

1 蔡青山;柴胡青陳湯加減治療氣郁咳嗽48例[J];河北中醫(yī);2005年08期

2 馬汴梁;;淺論氣郁[J];山東中醫(yī)雜志;1986年02期

3 王建剛;;淺論氣郁[J];陜西中醫(yī)函授;1989年04期

4 陳霞波;蘇瓊;;血虛氣郁體質從肝論[J];中國民族民間醫(yī)藥;2010年24期

5 劉美之;倪誠;;中醫(yī)氣郁體質與方藥干預研究述評[J];山西中醫(yī)學院學報;2012年03期

6 王鵬;;氣郁體質的研究進展[J];中國保健營養(yǎng);2013年06期

7 ;妊娠氣郁案[J];浙江中醫(yī)雜志;2001年12期

8 馮娜;賀娟;王琦;;氣郁體質相關差異基因研究[J];中國中西醫(yī)結合雜志;2011年01期

9 ;氣郁體質怎樣養(yǎng)生[J];科技視界;2011年13期

10 劉存光;;氣郁體質的養(yǎng)生:演藝明星多氣郁(上)[J];卓越理財;2013年10期

相關會議論文 前2條

1 王芙蓉;周鳳珍;宋蕾;;氣郁體質之食藥養(yǎng)生[A];中華中醫(yī)藥學會第八屆中醫(yī)體質研討會暨中醫(yī)健康狀態(tài)認知與體質辨識研究論壇論文集[C];2010年

2 蘇榮立;范宇;;淺談治氣郁失眠癥之體會[A];中華中醫(yī)藥學會中醫(yī)、中西醫(yī)結合治療常見病研討會論文集[C];2007年

相關重要報紙文章 前3條

1 河北省滄州中西醫(yī)結合醫(yī)院治未病中心 侯獻兵;氣郁體質調養(yǎng)有招[N];中國中醫(yī)藥報;2013年

2 衣曉峰 張銳;調查顯示：哈爾濱八成市民體質“氣郁”兼“痰濕”[N];中國醫(yī)藥報;2014年

3 南京中醫(yī)藥大學周仲瑛名醫(yī)工作室 郭立中　朱W，

本文編號：2455439