【摘要】：利用電特性(electric properties,EPs;電導率和介電常數)作為特征值對生物組織進行區(qū)分(例如:正常組織vs.腫瘤組織)可以應用于疾病尤其是腫瘤的早期診斷。生物組織的電特性與組織生理病理狀態(tài)有密切的聯(lián)系,在生物組織離體后其電特性發(fā)生明顯變化,因此,在體測量的組織電特性數據更加真實,對疾病診斷有重要意義。本研究采用自制的小尺寸探頭,對種植1~4周(10只/周)人類乳腺癌(MDA MB 231)的BALB/c裸鼠模型的腫瘤組織及正常組織的EPs進行在體和離體測量,測量頻率范圍為0.5~5 MHz,并對腫瘤組織進行病理學檢測。對腫瘤組織及正常組織EPs數據進行分析得到裸鼠乳腺癌組織與正常組織的電導率和介電常數存在顯著差異(P0.01)。同一組織在體測量及離體測量數據存在顯著差異(P0.01)。對1~4周的乳腺癌腫瘤組織電特性數據分析得到在腫瘤發(fā)展過程中,其EPs產生變化。本研究結果表明小尺寸探頭測量的在體生物組織EPs與離體EPs有明顯差異,在體測量生物組織的EPs對根據EPs變化診斷早期癌癥有重要意義。
[Abstract]:Use electrical properties (electric properties,EPs; conductivity and dielectric constant) as characteristic values to distinguish biological tissues (for example: normal tissue vs.) Tumor tissue) can be used in the early diagnosis of diseases, especially tumors. The electrical properties of biological tissues are closely related to the physiological and pathological state of tissues, and the electrical properties of biological tissues have obvious changes after in vitro. Therefore, the electrical characteristics of tissues measured in vivo are more real and have important significance for the diagnosis of diseases. In this study, the in vivo and in vitro EPs of human breast cancer (MDA MB 231 implanted in nude mice were measured in vivo and in vitro by using a self-made small size probe. The frequency range of the measurement was 0.5? 5 MHz,. The EPs was measured in vivo and in vitro in nude mice with human breast cancer (BALB/c) implanted for 4 weeks (10 mice / week). Pathological examination was performed on the tumor tissue. The electrical conductivity and dielectric constant of breast cancer tissues in nude mice were significantly different from those in normal tissues (P0.01). The EPs data of tumor tissues and normal tissues were analyzed. There were significant differences between in vivo and in vitro measurements of the same tissue (P0.01). The data of electrical characteristics of breast cancer tissues from 1 to 4 weeks were analyzed and the changes of EPs were found in the course of tumor development. The results show that there is a significant difference between in vivo EPs and in vitro EPs measured by small size probe, and in vivo measurement of EPs in biological tissue is of great significance for the diagnosis of early cancer according to the changes of EPs.
【作者單位】： 中國醫(yī)學科學院北京協(xié)和醫(yī)學院生物醫(yī)學工程研究所;
【基金】：國家自然科學基金資助項目(81772004,61501523) 中國醫(yī)學科學院醫(yī)學與健康科技創(chuàng)新工程項目(2017-I2M-3-020)
【分類號】：R737.9
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本文編號：2444481