產(chǎn)生基質(zhì)的化生性乳腺癌六例臨床病理分析
發(fā)布時(shí)間：2019-01-02 15:46
【摘要】：目的產(chǎn)生基質(zhì)的化生性乳腺癌(matrix-producing metaplastic carcinoma of the breast,MPMC)較罕見(jiàn),病理形態(tài)非常特殊,容易導(dǎo)致誤診。本研究探討MPMC臨床病理學(xué)特征、診斷要點(diǎn)及鑒別診斷。方法收集2010-01-01-2016-01-01北京大學(xué)人民醫(yī)院MPMC患者6例�；颊呔鶠榕�,年齡42~73歲,中位年齡49歲。分析6例MPMC的臨床特點(diǎn),觀察其組織病理學(xué)表現(xiàn)并進(jìn)行免疫組化染色,同時(shí)復(fù)習(xí)相關(guān)文獻(xiàn)資料。結(jié)果腫瘤呈結(jié)節(jié)狀生長(zhǎng),部分區(qū)域呈浸潤(rùn)性生長(zhǎng)方式。結(jié)節(jié)周?chē)鸀榇笃掀映矆F(tuán),中央為黏液軟骨樣基質(zhì),可見(jiàn)壞死。6例上皮樣細(xì)胞團(tuán)均為乳腺浸潤(rùn)性導(dǎo)管癌,4例組織學(xué)分級(jí)呈Ⅲ級(jí)改變,2例為Ⅱ級(jí)。免疫組化6例患者中有4例ER、PR和C-erbB-2陰性,1例ER陽(yáng)性,1例C-erbB-2為+,6例CK5/6、S100、CK和Vimentin、EGFR陽(yáng)性。另做組織化學(xué)染色AB-PAS,6例均為陽(yáng)性。結(jié)論MPMC一種非常罕見(jiàn)的惡性腫瘤,診斷時(shí)需與葉狀腫瘤等鑒別,免疫組化有助于鑒別診斷。
[Abstract]:Objective Hyperplastic breast cancer (matrix-producing metaplastic carcinoma of the breast,MPMC) producing matrix is rare, and its pathological morphology is very special, which can easily lead to misdiagnosis. This study was to investigate the clinicopathological features, diagnostic features and differential diagnosis of MPMC. Methods six patients with MPMC in the people's Hospital of Peking University, 2010-01-01-2016-01 were collected. All the patients were female, aged 42 to 73 years, with a median age of 49 years. The clinical features of 6 cases of MPMC were analyzed, the histopathological manifestations and immunohistochemical staining were observed, and the related literatures were reviewed. Results the tumor was nodular, and some areas were infiltrating. There were large epithelioid nests around the nodules and mucinous chondroid matrix in the center. Necrosis was observed in 6 cases with infiltrating ductal carcinoma of the breast. Histological grade 鈪，
本文編號(hào)：2398687
[Abstract]:Objective Hyperplastic breast cancer (matrix-producing metaplastic carcinoma of the breast,MPMC) producing matrix is rare, and its pathological morphology is very special, which can easily lead to misdiagnosis. This study was to investigate the clinicopathological features, diagnostic features and differential diagnosis of MPMC. Methods six patients with MPMC in the people's Hospital of Peking University, 2010-01-01-2016-01 were collected. All the patients were female, aged 42 to 73 years, with a median age of 49 years. The clinical features of 6 cases of MPMC were analyzed, the histopathological manifestations and immunohistochemical staining were observed, and the related literatures were reviewed. Results the tumor was nodular, and some areas were infiltrating. There were large epithelioid nests around the nodules and mucinous chondroid matrix in the center. Necrosis was observed in 6 cases with infiltrating ductal carcinoma of the breast. Histological grade 鈪，
本文編號(hào)：2398687
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