【摘要】：目的:研究胃癌患者外周血T淋巴細(xì)胞亞群變化的臨床意義。方法:選取2015年10月至2016年5月北京世紀(jì)壇醫(yī)院腫瘤內(nèi)科收治的67例胃癌患者,抽取外周血,采用流式細(xì)胞術(shù)檢測T細(xì)胞及其亞群,同時(shí)抽取外周血檢測腫瘤標(biāo)記物CEA、CA199,對結(jié)果進(jìn)行分析比較,并對患者進(jìn)行隨訪。結(jié)果:67例胃癌患者中,Ⅲ期患者Tc(CD8+CD28+)均值為12.3±5.1,Ⅳ期患者Tc(CD8+CD28+)均值為9.9±4.6,兩者比較差異具有統(tǒng)計(jì)學(xué)意義(P=0.043);CEA升高的患者Tc(CD8+CD28+)均值為9.3±3.6,而CA199未升高的患者Tc(CD8+CD28+)均值為12.1±5.6(P=0.025)。CA199升高的患者Tc(CD8+CD28+)均值為9.3±4.2,而CEA未升高的患者Tc(CD8+CD28+)均值為12.1±5.3(P=0.029),Tc(CD8+CD28+)下降的患者較未下降的患者的總生存時(shí)間(overall survival,OS)降低(8.1個(gè)月vs.15.1個(gè)月,P=0.008)。結(jié)論:胃癌患者隨著TNM分期的提高,其機(jī)體的細(xì)胞免疫功能呈現(xiàn)逐漸下降的趨勢;CEA、CA199升高的患者Tc(CD8+CD28+)降低,二者呈負(fù)相關(guān);Tc(CD8+CD28+)降低,患者的OS縮短。
[Abstract]:Objective: to study the clinical significance of T lymphocyte subsets in peripheral blood of patients with gastric cancer. Methods: from October 2015 to May 2016, 67 patients with gastric cancer were selected from Department of Oncology, Beijing Shijitan Hospital. Peripheral blood was extracted, T cells and their subsets were detected by flow cytometry, and tumor marker CEA,CA199, was detected by peripheral blood. The results were analyzed and compared, and the patients were followed up. Results: in 67 patients with gastric cancer, the mean value of Tc (CD8 CD28) was 12.3 鹵5.1 in stage 鈪，

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