【摘要】：背景與目的肺粘液表皮樣癌(mucoepidermoid carcinoma,MEC)是罕見的肺部惡性腫瘤,其臨床特征及預(yù)后尚不完全明確,本研究旨在探討肺粘液表皮樣癌的臨床特征、診治方法及預(yù)后影響因素。方法回顧?quán)嵵荽髮W(xué)附屬腫瘤醫(yī)院2006年1月-2015年12月收治的29例肺MEC患者的臨床資料,對臨床特征、診斷方法、治療措施及預(yù)后進(jìn)行分析。結(jié)果全組29例患者占同期新診斷肺癌的0.16%(29/18,021),其中男性18例,女性11例;中位年齡45歲(10歲-79歲);高級別肺MEC 17例,低級別12例。6例患者行表皮生長因子受體(epidermal growth factor receptor,EGFR)基因檢測均未檢測到突變。行手術(shù)為主的綜合治療17例,非手術(shù)治療12例。中位隨訪時間35(5-114)個月,至隨訪結(jié)束,17例患者已死亡。全組1年、3年、5年生存率分別為65.5%、51.2%和39.4%,中位生存時間37個月。結(jié)論肺MEC發(fā)病率低,臨床表現(xiàn)缺乏特異性,確診主要依據(jù)術(shù)后組織病理,并輔以免疫組化標(biāo)記結(jié)果,手術(shù)是主要的治療方法,病理級別以高級別為主,其預(yù)后與組織學(xué)分級、臨床分期密切相關(guān),EGFR酪氨酸激酶抑制劑(EGFR-tyrosine kinase inhibitor,EGFR-TKI)有望改善肺MEC的預(yù)后。
[Abstract]:Background & objective Pulmonary mucoepidermoid carcinoma (mucoepidermoid carcinoma,MEC) is a rare malignant tumor of the lung. Its clinical features and prognosis are not completely clear. This study aims to explore the clinical features, diagnosis and treatment methods and prognostic factors of pulmonary mucoepidermoid carcinoma. Methods the clinical data of 29 patients with pulmonary MEC admitted from January 2006 to December 2015 in affiliated Cancer Hospital of Zhengzhou University were reviewed. The clinical features, diagnostic methods, treatment measures and prognosis were analyzed. Results 29 patients accounted for 0.16% (29 / 18021) of newly diagnosed lung cancer in the same period, including 18 males and 11 females, with a median age of 45 years (10-79 years). There were 17 cases of high grade MEC and 12 cases of low grade. No mutation was detected in the epidermal growth factor receptor (epidermal growth factor receptor,EGFR) gene in 6 cases. 17 cases were treated with combined operation and 12 cases with non-operative treatment. The median follow-up time was 35 (5-114) months. By the end of follow-up, 17 patients had died. The 1-year, 3-year and 5-year survival rates were 65.5% and 39.4%, respectively. The median survival time was 37 months. Conclusion Pulmonary MEC has a low incidence and lack of specificity in clinical manifestations. The diagnosis is mainly based on postoperative histopathology and immunohistochemical results. Surgery is the main treatment method, and the pathological grade is mainly high grade, its prognosis and histological grading. EGFR tyrosine kinase inhibitor (EGFR-tyrosine kinase inhibitor,EGFR-TKI) may improve the prognosis of pulmonary MEC.
【作者單位】： 鄭州大學(xué)附屬腫瘤醫(yī)院呼吸內(nèi)科;
【分類號】：R734.2

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