【摘要】：目的:初步分析國內(nèi)外口腔鱗癌的相對生存率現(xiàn)況和變化,為口腔鱗癌診治工作的研究提供基礎(chǔ)數(shù)據(jù)和初步的效果評價。方法:計算機檢索相關(guān)期刊論文(CJFD)、中國知網(wǎng)全文數(shù)據(jù)庫、萬方全文數(shù)據(jù)庫、PUBMED數(shù)據(jù)庫等,系統(tǒng)的搜集對1970年1月至2016年12月公開發(fā)表的、以人群為基礎(chǔ)的口腔鱗癌的生存資料進(jìn)行分析,嚴(yán)格制定納入標(biāo)準(zhǔn):發(fā)病的解剖范圍包括頰粘膜、上下牙齦、磨牙后區(qū)、口底、硬腭和舌前2/3,病理分型為鱗狀細(xì)胞癌,數(shù)據(jù)均來自國家或地區(qū)的以人群為基礎(chǔ)的生存資料,以資料中的相對生存率(relative survival rate,RSR)為研究指標(biāo),對不同國家或地區(qū)間口腔鱗癌的相對生存率及其變化進(jìn)行比較。結(jié)果:初步檢索共搜集到相關(guān)文獻(xiàn)118篇。經(jīng)過篩選,將來源于全人群、提供了口腔鱗癌的觀察生存(observed survival rate,OSR)和相對生存率(relative survival rate,RSR)的文獻(xiàn)保留,對生存信息重復(fù)不全或非全人群的資料進(jìn)行刪除,最終符合納入要求的文獻(xiàn)共有49篇,其中中文文獻(xiàn)14篇,英文文獻(xiàn)35篇。通過比較我們發(fā)現(xiàn)從1970年至1999年,不同國家和地區(qū)的口腔鱗癌的相對生存率均呈現(xiàn)穩(wěn)步提高狀態(tài),2000年至今部分國家或地區(qū)的口腔鱗癌相對生存率提高緩慢或呈相對持平狀態(tài)。我國總體口腔鱗癌5年相對生存率較西方發(fā)達(dá)國家仍處于相對落后狀態(tài)。中國上海地區(qū)的口腔鱗癌5年相對生存率隨著時間的發(fā)展呈穩(wěn)步提高的趨勢,到21世紀(jì)初期已達(dá)到世界先進(jìn)水平。北京、天津、臺灣等地區(qū)的口腔鱗癌相對生存率高于江蘇啟東、福建及湖南省的生存率水平。國外資料表明,歐洲和美國的口腔鱗癌相對生存率較高,而南美洲、非洲的生存率較低�？傮w上大部分國家或地區(qū)男性的口腔鱗癌相對生存率低于女性;口腔鱗癌的相對生存率與年齡的增長呈負(fù)相關(guān)。結(jié)論:隨著時間的發(fā)展口腔鱗癌的生存率呈不斷提高,但整體仍處于較低的水平;我國口腔鱗癌生存率水平有所提高,部分地區(qū)接近或達(dá)到西方發(fā)達(dá)國家水平,部分地區(qū)仍有一定差距。
[Abstract]:Objective: to analyze the relative survival rate of oral squamous cell carcinoma (OSCC) at home and abroad, and to provide basic data and preliminary effect evaluation for the diagnosis and treatment of OSCC. Methods: the full text database of (CJFD), Wanfang full text database and PUBMED database were searched by computer. The data were collected and published from January 1970 to December 2016. The survival data of oral squamous cell carcinoma (OSCC) based on population were analyzed, and the inclusion criteria were strictly formulated: the anatomical range of the disease included buccal mucosa, upper and lower gingiva, posterior molar region, floor of mouth, hard palate and front of tongue, and pathological classification was squamous cell carcinoma. The relative survival rate of oral squamous cell carcinoma (OSCC) in different countries or regions was compared with the relative survival rate (relative survival rate,RSR). Results: a total of 118 literatures were preliminarily searched. After screening, the literature of oral squamous cell carcinoma (observed survival rate,OSR) and relative survival rate (relative survival rate,RSR) were preserved, and the data of incomplete or incomplete survival information were deleted. There were 49 articles, 14 in Chinese and 35 in English. From 1970 to 1999, we found that the relative survival rate of oral squamous cell carcinoma (OSCC) in different countries and regions increased steadily, and the relative survival rate of OSCC in some countries or regions has been increasing slowly or in a relatively flat state since 2000. The overall 5-year relative survival rate of oral squamous cell carcinoma in China is still relatively backward than that in western developed countries. The 5-year relative survival rate of oral squamous cell carcinoma (OSCC) in Shanghai, China, has steadily increased with the development of time, and has reached the advanced level of the world by the beginning of 21 ~ (st) century. The relative survival rate of oral squamous cell carcinoma in Beijing, Tianjin and Taiwan was higher than that in Qidong, Fujian and Hunan provinces. Foreign data show that the relative survival rate of oral squamous cell carcinoma is higher in Europe and the United States, but lower in South America and Africa. In general, the relative survival rate of male oral squamous cell carcinoma was lower than that of female, and the relative survival rate of oral squamous cell carcinoma was negatively correlated with the increase of age. Conclusion: the survival rate of oral squamous cell carcinoma (OSCC) increases with the development of time, but the overall survival rate is still at a low level. The survival rate of oral squamous cell carcinoma (OSCC) in China has been improved, some areas are close to or up to the level of western developed countries, and some areas still have a certain gap.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R739.8

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