發(fā)布時(shí)間：2018-11-26 14:16

【摘要】：目的研究切除修復(fù)交叉互補(bǔ)基因1(ercc1)在食管鱗癌中的表達(dá)規(guī)律與食管鱗癌患者預(yù)后的關(guān)系及其臨床意義。方法采用疫組織化學(xué)染色法檢測(cè)110例食管鱗癌組織及110例遠(yuǎn)癌組織中ercc1基因的表達(dá)水平,分析ercc1基因的表達(dá)水平與食管鱗癌臨床病理特征的關(guān)系以及預(yù)后之間的關(guān)系。結(jié)果ercc1基因在食管鱗癌組織中高表達(dá)69例,低表達(dá)41例,高表達(dá)率為63%,在遠(yuǎn)癌組織中高表達(dá)8例,低表達(dá)102例,高表達(dá)率為7%;ercc1基因的陽(yáng)性表達(dá)與食管鱗癌患者年齡(χ2=0.006,P=0.940)、性別(χ2=0.034,P=0.854)、腫瘤大小(χ2=1.844,P=0.175)、腫瘤浸潤(rùn)深度(χ2=0.020,P=0.889)、淋巴結(jié)轉(zhuǎn)移情況(χ2=0.979,P=0.323)以及酗酒史(χ2=3.816,P=0.051)無(wú)相關(guān)關(guān)系,而與食管鱗狀細(xì)胞癌患者分化程度(χ2=4.542,P=0.033)和病理分期(χ2=6.203,P=0.013)存在相關(guān)性;并且ercc1基因的表達(dá)水平與食管鱗癌患者預(yù)后有相關(guān)關(guān)系。結(jié)論ercc1基因在食管鱗狀細(xì)胞癌組織中的高表達(dá)率遠(yuǎn)高于遠(yuǎn)癌組織,并且erc c1基因的表達(dá)與食管鱗狀細(xì)胞癌患者的細(xì)胞分化程度和病理分期存在相關(guān)性。且ercc1基因的高表達(dá)影響患者預(yù)后,ercc1基因高表達(dá)患者的生存時(shí)間短于ercc1基因低表達(dá)患者,因此ercc1基因與食管鱗狀細(xì)胞癌的發(fā)生發(fā)展存在相關(guān)性,并且可作為食管鱗狀細(xì)胞癌患者預(yù)測(cè)預(yù)后的指標(biāo)。
[Abstract]:Objective to study the relationship between the expression of cross complementary gene 1 (ercc1) in esophageal squamous cell carcinoma and the prognosis of esophageal squamous cell carcinoma and its clinical significance. Methods the expression of ercc1 gene in 110 cases of esophageal squamous cell carcinoma and 110 cases of distant carcinoma was detected by immunohistochemical staining. The relationship between the expression of ercc1 gene and the clinicopathological features and prognosis of esophageal squamous cell carcinoma was analyzed. Results there were 69 cases of high expression of ercc1 gene and 41 cases of low expression of ercc1 gene in esophageal squamous cell carcinoma, the high expression rate was 63%. The high expression rate of ercc1 gene in distant carcinoma was 8 cases and low expression in 102 cases, the high expression rate was 7%. The positive expression of ercc1 gene was associated with the age of esophageal squamous cell carcinoma (蠂 2 + 0.006), sex (蠂 2 0. 034), tumor size (蠂 2) 1.84 4 (P 0. 175), depth of tumor invasion (蠂 2 0. 020) and tumor invasion (P 0. 889). There was no correlation between lymph node metastasis (蠂 2 / 0 979) and history of alcoholism (蠂 2 / 3.816 / P = 0.051), but there was no correlation between lymph node metastasis and differentiation degree (蠂 2 / 4.542) and pathological stage (蠂 2 / 6.203) in esophageal squamous cell carcinoma. There was a correlation between P0. 013 and P0. 013. The expression of ercc1 gene was correlated with the prognosis of esophageal squamous cell carcinoma. Conclusion the high expression rate of ercc1 gene in esophageal squamous cell carcinoma is much higher than that in distal carcinoma, and the expression of erc C1 gene is correlated with the degree of cell differentiation and pathological stage of esophageal squamous cell carcinoma. The survival time of patients with high expression of ercc1 gene was shorter than that of patients with low expression of ercc1 gene. Therefore, there was a correlation between ercc1 gene and the occurrence and development of esophageal squamous cell carcinoma. It can be used as a predictor of prognosis in esophageal squamous cell carcinoma.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R735.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前8條

1 李勵(lì);劉勝楠;鄭唯強(qiáng);張俊潔;;ERCC1和TUBB3在卵巢癌組織中的表達(dá)及其臨床意義[J];中國(guó)臨床醫(yī)學(xué);2016年05期

2 蔡祖艾;張瑋;;ERCC1基因19007C/T多態(tài)性與上皮性卵巢癌鉑類(lèi)聯(lián)合化療反應(yīng)關(guān)系的Meta分析[J];中國(guó)癌癥防治雜志;2015年04期

3 王琳;陳俊民;邢雪花;王海霞;孫達(dá)統(tǒng);楊生輝;黃琰菁;盛莉;邱純;陳鄧林;;進(jìn)展期胃癌ERCC1表達(dá)與含鉑方案化療療效相關(guān)性Meta分析[J];中華腫瘤防治雜志;2015年06期

4 向安玲;莊瑞春;彭玲;;ERCC1 118C/T基因多態(tài)性與卵巢癌患者鉑類(lèi)化療臨床結(jié)局關(guān)系的系統(tǒng)評(píng)價(jià)[J];中國(guó)藥房;2014年48期

5 杜培;王沂峰;張曉薇;陳禮全;陳國(guó)勤;;ERCC1和BRCA1表達(dá)與原發(fā)性上皮性卵巢癌患者臨床因素及鉑類(lèi)化療敏感性的研究[J];醫(yī)藥導(dǎo)報(bào);2014年06期

6 周倩茹;邱紅;胡廣原;龍國(guó)賢;劉東伯;莊亮;胡國(guó)清;;ERCC1和FGFR2在胃癌組織中的表達(dá)及其臨床意義[J];腫瘤防治研究;2012年11期

7 丁征平;張杰;邵晉晨;;ERCC1表達(dá)對(duì)I期非小細(xì)胞肺癌患者術(shù)后生存率的影響[J];中國(guó)肺癌雜志;2010年05期

8 蘇彤;趙立軍;常文軍;王國(guó)萍;何永超;孫沁瑩;張宏偉;李強(qiáng);曹廣文;;ERCC1、XPD和BRCA1基因多態(tài)與晚期非小細(xì)胞肺癌患者鉑類(lèi)藥物化療效果的相關(guān)性[J];第二軍醫(yī)大學(xué)學(xué)報(bào);2010年02期

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