【摘要】：目的對LCH皮損組織炎癥反應模式進行分析,探討其病理特征與臨床表現、預后的關系。方法選擇有皮損表現的25例LCH患者作為研究對象,分析患者皮損組織炎癥反應模式,通過免疫組化技術檢測患者皮損組織中ki-67、CD163的表達情況,采集分析患者臨床資料,電話隨訪患者治療情況以及預后。所得數據用SPSS15.0統(tǒng)計軟件進行統(tǒng)計學分析。結果(1)LCH皮損組織中有兩種炎癥反應模式,一種為表現為朗格漢斯組織細胞周圍多量組織細胞、淋巴細胞浸潤模式,另一種表現為朗格漢斯組織細胞周圍稀疏組織細胞、淋巴細胞浸潤模式。(2)25例LCH皮損組織中ki-67陽性密度平均為16.99%?12.02%,浸潤炎細胞CD163陽性密度為16.71%?12.17%。在僅累及皮膚的SS-LCH中,ki-67及CD163陽性密度均值分別為14.13%?8.47%和24.64%?13.91%;累及皮膚和內臟器官的MS-LCH中ki-67及CD163陽性密度均值分別為17.94%?13.02%和14.06%?10.61%。SS-LCH與MS-LCH比較,ki-67陽性細胞浸潤密度差異無統(tǒng)計學意義(P0.05),CD163陽性細胞浸潤密度差異具有統(tǒng)計學意義(P0.05)。結論(1)LCH皮損組織中朗格漢斯組織細胞增殖指數水平較低,增殖指數水平與患者內臟是否累及無相關性。(2)CD163陽性炎性細胞浸潤密度可能與LCH侵襲進展相關。
[Abstract]:Objective to study the relationship between pathological features and clinical manifestations and prognosis of LCH lesions. Methods 25 cases of LCH patients with lesions were selected as the study objects. The inflammatory response patterns in the lesions were analyzed. The expression of ki-67,CD163 in the lesions was detected by immunohistochemical technique, and the clinical data of the patients were collected and analyzed. The treatment and prognosis of the patients were followed up by telephone. The data were analyzed by SPSS15.0 software. Results (1) there were two inflammatory response patterns in the lesions of LCH, one was the infiltration of lymphocytes around Langerhans tissue cells, the other was sparse tissue cells around Langerhans tissue cells. (2) in 25 cases of LCH, the average positive density of ki-67 was 16.990.The positive density of CD163 in infiltrative cells was 16.71 and 12.172.The positive density of CD163 in infiltrative cells was 16.71 and 12.17 respectively. In SS-LCH with only skin involvement, the average positive densities of ki-67 and CD163 were 14.138.47% and 24.64%, 13.91%, respectively. The average positive densities of ki-67 and CD163 in MS-LCH involving skin and visceral organs were 17.9413.02% and 13.02%, respectively, and 14.06%?10.61%.SS-LCH were compared with MS-LCH. There was no significant difference in the infiltration density of ki-67 positive cells (P0.05), but there was significant difference in the infiltration density of CD163 positive cells (P0.05). Conclusion (1) the level of Langerhans' cell proliferation index in LCH lesions is low, and there is no correlation between the proliferation index and visceral involvement. (2) the density of CD163 positive inflammatory cells infiltration may be related to the invasion and progression of LCH.
【學位授予單位】：廣西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R733.3

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