【摘要】：目的對(duì)LCH皮損組織炎癥反應(yīng)模式進(jìn)行分析,探討其病理特征與臨床表現(xiàn)、預(yù)后的關(guān)系。方法選擇有皮損表現(xiàn)的25例LCH患者作為研究對(duì)象,分析患者皮損組織炎癥反應(yīng)模式,通過(guò)免疫組化技術(shù)檢測(cè)患者皮損組織中ki-67、CD163的表達(dá)情況,采集分析患者臨床資料,電話(huà)隨訪患者治療情況以及預(yù)后。所得數(shù)據(jù)用SPSS15.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果(1)LCH皮損組織中有兩種炎癥反應(yīng)模式,一種為表現(xiàn)為朗格漢斯組織細(xì)胞周?chē)嗔拷M織細(xì)胞、淋巴細(xì)胞浸潤(rùn)模式,另一種表現(xiàn)為朗格漢斯組織細(xì)胞周?chē)∈杞M織細(xì)胞、淋巴細(xì)胞浸潤(rùn)模式。(2)25例LCH皮損組織中ki-67陽(yáng)性密度平均為16.99%?12.02%,浸潤(rùn)炎細(xì)胞CD163陽(yáng)性密度為16.71%?12.17%。在僅累及皮膚的SS-LCH中,ki-67及CD163陽(yáng)性密度均值分別為14.13%?8.47%和24.64%?13.91%;累及皮膚和內(nèi)臟器官的MS-LCH中ki-67及CD163陽(yáng)性密度均值分別為17.94%?13.02%和14.06%?10.61%。SS-LCH與MS-LCH比較,ki-67陽(yáng)性細(xì)胞浸潤(rùn)密度差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),CD163陽(yáng)性細(xì)胞浸潤(rùn)密度差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論(1)LCH皮損組織中朗格漢斯組織細(xì)胞增殖指數(shù)水平較低,增殖指數(shù)水平與患者內(nèi)臟是否累及無(wú)相關(guān)性。(2)CD163陽(yáng)性炎性細(xì)胞浸潤(rùn)密度可能與LCH侵襲進(jìn)展相關(guān)。
[Abstract]:Objective to study the relationship between pathological features and clinical manifestations and prognosis of LCH lesions. Methods 25 cases of LCH patients with lesions were selected as the study objects. The inflammatory response patterns in the lesions were analyzed. The expression of ki-67,CD163 in the lesions was detected by immunohistochemical technique, and the clinical data of the patients were collected and analyzed. The treatment and prognosis of the patients were followed up by telephone. The data were analyzed by SPSS15.0 software. Results (1) there were two inflammatory response patterns in the lesions of LCH, one was the infiltration of lymphocytes around Langerhans tissue cells, the other was sparse tissue cells around Langerhans tissue cells. (2) in 25 cases of LCH, the average positive density of ki-67 was 16.990.The positive density of CD163 in infiltrative cells was 16.71 and 12.172.The positive density of CD163 in infiltrative cells was 16.71 and 12.17 respectively. In SS-LCH with only skin involvement, the average positive densities of ki-67 and CD163 were 14.138.47% and 24.64%, 13.91%, respectively. The average positive densities of ki-67 and CD163 in MS-LCH involving skin and visceral organs were 17.9413.02% and 13.02%, respectively, and 14.06%?10.61%.SS-LCH were compared with MS-LCH. There was no significant difference in the infiltration density of ki-67 positive cells (P0.05), but there was significant difference in the infiltration density of CD163 positive cells (P0.05). Conclusion (1) the level of Langerhans' cell proliferation index in LCH lesions is low, and there is no correlation between the proliferation index and visceral involvement. (2) the density of CD163 positive inflammatory cells infiltration may be related to the invasion and progression of LCH.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R733.3

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