【摘要】：目的探討前列腺癌骨轉(zhuǎn)移的臨床特點(diǎn)及其危險(xiǎn)因素。方法回顧性分析2006年6月-2016年6月南昌大學(xué)第一附屬醫(yī)院收治的、經(jīng)穿刺活檢或術(shù)后病理檢查確診為前列腺癌患者的臨床資料,記錄首次入院時(shí)的一般資料、化驗(yàn)檢查結(jié)果及病理切片Gleason評分,分析各臨床因素與骨轉(zhuǎn)移發(fā)生的關(guān)系,明確骨轉(zhuǎn)移發(fā)生的相關(guān)危險(xiǎn)因素。結(jié)果共納入585例前列腺癌患者,其中發(fā)生骨轉(zhuǎn)移228例,無骨轉(zhuǎn)移357例。在骨轉(zhuǎn)移患者中,骨盆轉(zhuǎn)移發(fā)生率最高,占81.58%,其次是脊柱轉(zhuǎn)移(63.16%)和肋骨轉(zhuǎn)移(58.33%),鎖骨轉(zhuǎn)移最少(14.47%)。Logistic回歸分析顯示年齡71.5歲、堿性磷酸酶(ALP)85.5U/L、前列腺特異性抗原(PSA)79.88μg/L和Gleason評分7.5分是前列腺癌骨轉(zhuǎn)移的危險(xiǎn)因素。ROC曲線分析顯示,上述各因素診斷骨轉(zhuǎn)移的靈敏度分別為56.1%、66.7%、68.4%、56.1%,特異度分別為56.6%、81.8%、70.0%、65.3%。結(jié)論前列腺癌骨轉(zhuǎn)移以骨盆轉(zhuǎn)移最為多見,年齡、ALP、PSA及Gleason評分是前列腺癌發(fā)生骨轉(zhuǎn)移的危險(xiǎn)因素。
[Abstract]:Objective to investigate the clinical features and risk factors of bone metastasis in prostate cancer. Methods the clinical data of patients with prostate cancer diagnosed by puncture biopsy or postoperative pathological examination in the first affiliated Hospital of Nanchang University from June 2006 to June 2016 were analyzed retrospectively, and the general data of the first admission were recorded. The relationship between clinical factors and bone metastasis was analyzed, and the related risk factors of bone metastasis were identified. Results there were 585 cases of prostate cancer including 228 cases of bone metastasis and 357 cases of no bone metastasis. The incidence of pelvic metastasis was the highest (81.58%), followed by spinal metastasis (63.16%) and rib metastasis (58.33%), and clavicle metastasis was the least (14.47%) by). Logistic regression analysis. Alkaline phosphatase (ALP) 85.5 U / L, prostate specific antigen (PSA) 79.88 渭 g / L and Gleason score 7.5 were risk factors for bone metastasis of prostate cancer. The sensitivity of the above factors in the diagnosis of bone metastasis was 56.1 and 68.7, and the specificity was 56.6 and 81.8, respectively. Conclusion pelvic metastasis is the most common bone metastasis in prostate cancer. Age, ALP,PSA and Gleason scores are the risk factors for bone metastasis of prostate cancer.
【作者單位】： 南昌大學(xué)第一附屬醫(yī)院骨科;
【基金】：江西省主要學(xué)科帶頭人資助計(jì)劃(20162BCB22022) 江西省杰出青年人才資助計(jì)劃(20162BCB23057)~~
【分類號】：R737.25

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