【摘要】：目的:探索結(jié)直腸癌(Colorectal cancer,CRC)患者外周血中的中期因子(Midkine,MK)在診斷疾病和對結(jié)直腸癌預后判斷方面的價值。方法:以2014年1月到12月就診于山西省腫瘤醫(yī)院結(jié)直腸肛門外科的126例結(jié)直腸癌患者為研究組,以山西省腫瘤醫(yī)院體檢中心75例健康體檢者為對照組,分別檢測兩組外周血中MK蛋白以及癌胚抗原(Carcino-embryonic antigen,CEA)的含量。兩組樣本分別采用成組t檢驗進行比較,多組樣本采用方差分析方法及LSD-t檢驗方法進行比較。結(jié)果:結(jié)直腸癌實驗組較健康體檢對照組外周血MK蛋白含量明顯增高(p0.01)。I+II期、III期、IV期結(jié)直腸癌患者外周血中MK蛋白含量依次增高,分別為431±88、498±71、600±78 pg/ml,對三者進行兩兩比較,差異均有統(tǒng)計學意義(p0.01)。在診斷結(jié)直腸癌方面,外周血MK蛋白的診斷價值要高于外周血CEA,通過計算二者ROC曲線下方面積分別為0.878和0.824,其差異有統(tǒng)計學意義(p0.05)。結(jié)論:(1)外周血MK蛋白在診斷結(jié)直腸癌方面要優(yōu)于傳統(tǒng)腫瘤標記物CEA。(2)MK的升高也預示著結(jié)直腸癌患者較差的預后,表明外周血MK可能成為診治結(jié)直腸癌的有效生物學標記物。
[Abstract]:Objective: to explore the value of metaphase factor (Midkine,MK) in peripheral blood of patients with colorectal cancer (Colorectal cancer,CRC) in diagnosis and prognosis of colorectal cancer. Methods: from January to December, 2014, 126 patients with colorectal and anal surgery in Shanxi Cancer Hospital were selected as study group and 75 healthy persons in Shanxi Cancer Hospital as control group. The contents of MK protein and carcinoembryonic antigen (Carcino-embryonic antigen,CEA) in peripheral blood were measured. Two groups of samples were compared by group t test, and many groups were compared by ANOVA and LSD-t test. Results: the content of MK protein in peripheral blood of colorectal cancer group was significantly higher than that of healthy control group (p0.01). I II phase, III phase, IV phase, MK protein content was 431 鹵88498 鹵71600 鹵78 pg/ml, respectively). The differences were statistically significant (p 0.01). In the diagnosis of colorectal cancer, the diagnostic value of peripheral blood MK protein was higher than that of peripheral blood CEA,. The area under the ROC curve was 0.878 and 0.824, respectively, and the difference was statistically significant (p0.05). Conclusion: (1) the increase of MK protein in peripheral blood is better than that of CEA. (2) MK in the diagnosis of colorectal cancer. The results suggest that peripheral blood MK may be an effective biological marker for the diagnosis and treatment of colorectal cancer.
【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R735.34

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