【摘要】：目的:總結(jié)、探討無(wú)功能性胰腺神經(jīng)內(nèi)分泌腫瘤的診斷和外科治療特點(diǎn),進(jìn)一步加深對(duì)該病的認(rèn)識(shí)。方法:回顧性分析2002年1月至2014年12月福建醫(yī)科大學(xué)附屬第一醫(yī)院收治的16例無(wú)功能性胰腺神經(jīng)內(nèi)分泌腫瘤患者的臨床資料,分析、總結(jié)其臨床特點(diǎn)。結(jié)果:43.8%體檢發(fā)現(xiàn),出現(xiàn)臨床癥狀中:50.0%腹部悶痛、25.0%腹部包塊;92.3%初診BMI正�；虺亍z測(cè)AFP、CEA、CA125、CA199均陰性。腫瘤93.8%單發(fā)、6.2%多發(fā)(胰頭1個(gè)、胰體1個(gè)),最大直徑平均5.16cm,94.1%≥2.0cm、52.9%≥5.0cm;41.2%合并囊性變,23.5%合并鈣化;部位:胰頭47.1%、胰體35.3%、胰尾17.6%。B超、CT、MRI檢出率均為100%;9例行B超檢查,表現(xiàn):77.8%界清,88.9%低回聲;15例行CT檢查,表現(xiàn):62.5%界清,平掃93.8%低密度,增強(qiáng)86.7%明顯強(qiáng)化,其中86.7%不均勻強(qiáng)化;4例行MRI檢查,表現(xiàn):平掃75.0%T1WI低信號(hào)、100%T2WI高信號(hào),增強(qiáng)100%明顯強(qiáng)化。CT掃描聯(lián)合鈣化表現(xiàn)、CT掃描聯(lián)合囊性變表現(xiàn)、CT掃描聯(lián)合鈣化與囊性變表現(xiàn)、聯(lián)合CT平掃低密度與增強(qiáng)明顯強(qiáng)化表現(xiàn)、聯(lián)合B超低回聲與CT平掃低密度增強(qiáng)明顯強(qiáng)化表現(xiàn)者可降低誤診率。13行手術(shù)切除,3例非手術(shù)治療;15例獲得隨訪,早期患者、術(shù)后患者預(yù)后較好。結(jié)論:無(wú)功能性胰腺神經(jīng)內(nèi)分泌腫瘤臨床癥狀不典型,早期診斷困難,但影像學(xué)表現(xiàn)有特異之處;早期手術(shù)切除預(yù)后良好。
[Abstract]:Objective: to investigate the diagnosis and surgical treatment of nonfunctional neuroendocrine tumors of pancreas. Methods: the clinical data of 16 patients with nonfunctional pancreatic neuroendocrine tumors admitted to the first affiliated Hospital of Fujian Medical University from January 2002 to December 2014 were retrospectively analyzed and their clinical characteristics were summarized. Results: 43.8% of the clinical symptoms were found: 50.0% abdominal pain, 25.0% abdominal mass and 92.3% BMI were normal or overweight. AFP,CEA,CA125,CA199 was negative. 93.8% of the tumors were single, 6.2% had multiple tumors (1 head of pancreas and 1 body of pancreas), and the mean maximum diameter was 5.16 cm ~ (-1) 鈮，

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