【摘要】：目的 :探討血管內(nèi)皮生長因子A(vascular endothelial growth factor A,VEGFA)和血管內(nèi)皮生長因子受體2(vascular endothelial growth factor receptor 2,VEGFR2)與肺腺癌患者術后無病生存(disease-free survival,DFS)之間的相關性。方法:選擇114例肺腺癌術后腫瘤組織標本,應用免疫組織化學法(immunohistochemistry,IHC)檢測VEGFA及VEGFR2蛋白的表達情況。收集肺腺癌患者的性別、年齡、吸煙情況、腫瘤大小、陽性淋巴結(positive lymph nod,PLN)數(shù)目、臨床分期和術后治療情況等臨床資料,分析VEGFA和VEGFR2與這些臨床特征的相關性。COX比例風險回歸模型分析影響肺腺癌患者術后DFS的相關因素。結果:IHC檢測結果顯示,VEGFA和VEGFR2在NSCLC患者肺腺癌組織中的陽性表達率均為46.49%(53/114)。VEGFA蛋白的表達與患者的臨床特征無顯著相關性,而VEGFR2蛋白的表達與腫瘤大小存在負相關(P=0.03)。單因素分析顯示,VEGFA與VEGFR2蛋白的表達與患者DFS無顯著相關性。腫瘤大小4 cm(相對風險為2.29,95%可信區(qū)間為1.32~3.97;P=0.003)和PLN數(shù)≥2個(相對風險為2.15,95%可信區(qū)間為1.27~3.64;P=0.005)是肺腺癌患者術后DFS的獨立危險因素。結論:VEGFA和VEGFR2蛋白的表達與肺腺癌患者術后DFS無顯著相關性。腫瘤大小4 cm和PLN數(shù)≥2個是肺腺癌患者術后DFS的獨立影響因素。
[Abstract]:Objective: to investigate the relationship between vascular endothelial growth factor (A (vascular endothelial growth factor) and vascular endothelial growth factor receptor 2 (vascular endothelial growth factor receptor 2 VEGF R2 and disease-free survival (disease-free survival,DFS) in patients with lung adenocarcinoma. Methods: immunohistochemical method (immunohistochemistry,IHC) was used to detect the expression of VEGFA and VEGFR2 protein in 114 cases of lung adenocarcinoma after operation. The data of sex, age, smoking status, tumor size, number of positive lymph nodes (positive lymph nod,PLN), clinical stage and postoperative treatment of lung adenocarcinoma patients were collected. The correlation between VEGFA and VEGFR2 and these clinical features was analyzed. COX proportional risk regression model was used to analyze the related factors of postoperative DFS in patients with lung adenocarcinoma. Results: IHC showed that the positive expression rate of VEGFA and VEGFR2 was 46.49% (53 / 114). VEGFA protein was not correlated with the clinical features of the patients with NSCLC), while the expression of VEGFR2 protein was negatively correlated with the tumor size (P0. 03). Univariate analysis showed that there was no significant correlation between the expression of VEGFA and VEGFR2 protein and DFS. Tumor size 4 cm (relative risk 2.29 95% CI = 1.32) and PLN number 鈮，

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