年輕乳腺癌患者保乳手術(shù)治療局部復(fù)發(fā)的影響因素研究
發(fā)布時(shí)間：2018-09-06 13:39
【摘要】：目的分析年輕乳腺癌患者保乳治療(BCT)后局部復(fù)發(fā)的影響因素。方法收集2005年1月至2010年1月于該院行BCT的患者360例,進(jìn)行回顧性分析。收集患者臨床和病理資料,包括腫瘤大小、淋巴結(jié)狀態(tài)、腫瘤TNM分期、病理類(lèi)型、切緣狀態(tài)、人表皮生長(zhǎng)因子受體2(Her-2)、雌激素受體(ER)/孕激素受體(PR)和Ki-67。采用單因素分析及Logistic回歸分析進(jìn)行獨(dú)立危險(xiǎn)因素分析。結(jié)果患者行BCT后局部復(fù)發(fā)率為10.56%。單因素分析顯示,腫瘤大小、TNM分期、病理分型和ER/PR比值均對(duì)年輕患者BCT后局部復(fù)發(fā)無(wú)影響(P0.05);淋巴結(jié)轉(zhuǎn)移、切緣狀態(tài)、Her-2和Ki-67均可影響年輕患者BCT后的局部復(fù)發(fā)率(P0.05)。Logistic回歸分析顯示,淋巴結(jié)狀態(tài)、Her-2和切緣狀態(tài)為年輕患者BCT后局部復(fù)發(fā)的獨(dú)立危險(xiǎn)因素(P0.05)。結(jié)論淋巴轉(zhuǎn)移、Her-2陽(yáng)性和切緣狀態(tài)是年輕乳腺癌患者行BCT后局部復(fù)發(fā)的影響因素。
[Abstract]:Objective to analyze the influencing factors of local recurrence after breast conserving therapy in young breast cancer patients with (BCT). Methods from January 2005 to January 2010, 360 patients with BCT were retrospectively analyzed. Collect clinical and pathological data of patients, including tumor size, lymph node status, tumor TNM staging, pathological type, margin status, human epidermal growth factor receptor 2 (Her-2), estrogen receptor (ER) / progesterone receptor (PR) and Ki-67. The independent risk factors were analyzed by single factor analysis and Logistic regression analysis. Results the local recurrence rate was 10.56% after BCT. Univariate analysis showed that tumor size and TNM staging, pathological classification and ER/PR ratio had no effect on local recurrence after BCT in young patients (P0.05), lymph node metastasis, margin Her-2 and Ki-67 could all affect the local recurrence rate of BCT in young patients (P0.05). Lymph node status Her-2 and margin state were independent risk factors for local recurrence after BCT in young patients (P0.05). Conclusion the positive rate of Her-2 and the margin of lymphatic metastasis are the influential factors for local recurrence after BCT in young breast cancer patients.
【作者單位】： 常州市第一人民醫(yī)院乳腺科;
【分類(lèi)號(hào)】：R737.9
[Abstract]:Objective to analyze the influencing factors of local recurrence after breast conserving therapy in young breast cancer patients with (BCT). Methods from January 2005 to January 2010, 360 patients with BCT were retrospectively analyzed. Collect clinical and pathological data of patients, including tumor size, lymph node status, tumor TNM staging, pathological type, margin status, human epidermal growth factor receptor 2 (Her-2), estrogen receptor (ER) / progesterone receptor (PR) and Ki-67. The independent risk factors were analyzed by single factor analysis and Logistic regression analysis. Results the local recurrence rate was 10.56% after BCT. Univariate analysis showed that tumor size and TNM staging, pathological classification and ER/PR ratio had no effect on local recurrence after BCT in young patients (P0.05), lymph node metastasis, margin Her-2 and Ki-67 could all affect the local recurrence rate of BCT in young patients (P0.05). Lymph node status Her-2 and margin state were independent risk factors for local recurrence after BCT in young patients (P0.05). Conclusion the positive rate of Her-2 and the margin of lymphatic metastasis are the influential factors for local recurrence after BCT in young breast cancer patients.
【作者單位】： 常州市第一人民醫(yī)院乳腺科;
【分類(lèi)號(hào)】：R737.9
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