【摘要】：目的探討乳腺癌新輔助化療(neoadjuvant chemotherapy,NCT)前后自噬的變化及其與XIAP變化的關系。方法應用免疫組化En Vision兩步法檢測NCT前后94對乳腺癌組織中p62和XIAP的表達,觀察NCT后p62和XIAP表達的變化情況,分析其相關性。結果 NCT前乳腺癌標本中,p62高表達率為51.1%(48/94),XIAP高表達率為84.0%(79/94);NCT后乳腺癌標本中,p62高表達率升高為81.9%(77/94),XIAP高表達率降低為35.1%(33/94)。即NCT后p62高表達率明顯升高,XIAP高表達率明顯降低(P均0.05)。NCT前后相比,p62表達升高的樣本率為73.4%,XIAP表達下降的樣本率為75.5%,且p62表達變化與XIAP表達變化呈顯著負相關(P0.01)。結論乳腺癌NCT后自噬增強與XIAP下調共存,且XIAP可能參與NCT后自噬增強的負性調節(jié)。
[Abstract]:Objective to investigate the changes of autophagy in breast cancer before and after neoadjuvant chemotherapy (neoadjuvant) and the relationship between autophagy and XIAP. Methods the expression of p62 and XIAP in 94 cases of breast cancer before and after NCT was detected by immunohistochemical en Vision two-step method. The expression of p62 and XIAP was observed after NCT, and the correlation between p62 and XIAP was analyzed. Results the high expression rate of p62 in breast cancer specimens before NCT was 51.1% (48 / 94). The high expression rate of XIAP was 84.0% (79 / 94). The high expression rate of p62 was increased to 81.9% (77 / 94) and decreased to 35.1% (33 / 94). That is to say, the high expression rate of p62 was significantly increased after NCT. The high expression rate of XIAP decreased significantly (P0. 05). The sample rate of increased p62 expression before and after NCT was 73.5%, and the change of p62 expression was negatively correlated with the change of XIAP expression (P0.01). Conclusion autophagy after NCT in breast cancer coexists with down-regulation of XIAP, and XIAP may participate in the negative regulation of autophagy after NCT.
【作者單位】： 安徽醫(yī)科大學病理學教研室;
【基金】：國家自然科學基金(81372476、81472493)
【分類號】：R737.9

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