【摘要】：研究目的:觀察總結化濕和胃飲聯(lián)合西醫(yī)治療對于含順鉑化療后濕阻中焦型惡心嘔吐的療效和安全型。研究方法:1、入組病例,分為對照組:單純使用西醫(yī)治療,本文主要通過地塞米松5mg+帕洛諾司瓊0.25mg治療嘔吐,及實驗組:在對照組的基礎上加用化濕和胃飲,各30例。2、患者含順鉑化療同時服用化濕和胃飲聯(lián)合西醫(yī)治療,與單純西醫(yī)治療一周內(nèi)惡心嘔吐的相關中醫(yī)及FLIE評分�；瘽窈臀革嬘衫ド绞兄嗅t(yī)醫(yī)院煎藥器統(tǒng)一濃煎,分2次口服,早晚各100ml。西醫(yī)化療方案包括:TP(紫杉醇135～175mg/m2+順鉑75mg/m2)、DP(多西他賽 75mg/m2+順鉑 75mg/m2)、GP(吉西他濱 1000mg/m2+順鉑 75mg/m2)、NP(長春瑞濱 25-30mg/m2+順鉑 75mg/m2)、GDP(吉西他濱1000mg/m2+順鉑 75mg/m2+地塞米松20mg)。輔以保肝(天晴甘美150mg靜滴)和護胃(泮托拉唑40mg靜滴)。通過觀察臨床指標(血常規(guī)、肝腎功能),惡心嘔吐中醫(yī)評分及惡心嘔吐FLIE評分,分別觀察化療第一、三、五、七天的相關評分,評判化濕和胃飲聯(lián)合西醫(yī)治療在含順鉑化療后濕阻中焦型惡心嘔吐的療效。3、統(tǒng)計學方法:數(shù)據(jù)處理采用SPSS統(tǒng)計分析軟件,兩組對比分析,定性資料采用x2檢驗,定量資料符合正態(tài)分布采用t檢驗。給出檢驗統(tǒng)計量及其對應的P值,以P≤0.05作為有統(tǒng)計學意義。結果:1、含順鉑化療后濕阻中焦型的表現(xiàn)為:惡心嘔吐、頭重、怠倦、脘悶、腹脹、納呆、口粘渴、喜飲,舌苔厚白或膩,脈緩等濕阻中焦證表現(xiàn)。化濕和胃飲聯(lián)合西醫(yī)治療對比單純的西醫(yī)治療含順鉑化療后濕阻中焦型惡心嘔吐在長期治療上有較好的臨床療效。2、化濕和胃飲聯(lián)合西醫(yī)治療相對單純西醫(yī)治療的療效相對較好,患者能明顯改善化療期間及化療后的惡心嘔吐反應,對于部分單純西醫(yī)治療不易改善的化療導致的惡心嘔吐,化濕和胃飲聯(lián)合西醫(yī)治療有一定的優(yōu)勢,能增加患者的耐受程度。3、化濕和胃飲聯(lián)合西醫(yī)治療含順鉑化療后濕阻中焦證惡心嘔吐在臨床指標方面,相對于單純西醫(yī)治療含順鉑化療后濕阻中焦型惡心嘔吐無明顯差異,不存在其他的副反應。通過本研究,我們可以看出化濕和胃飲對于化療后濕阻中焦證惡心嘔吐存在較好的治療作用,化濕和胃飲有利于化療后濕阻中焦證惡心嘔吐的輔助治療。結論:化濕和胃飲聯(lián)合西醫(yī)治療相對于單純西醫(yī)治療存在一定的優(yōu)勢。
[Abstract]:Objective: to observe the efficacy and safety of Huashi-Wei-Yin combined with western medicine in treating nausea and vomiting with dampness resistance and middle scorch after chemotherapy with cisplatin. Methods the patients were divided into control group and control group. The patients were treated with western medicine alone. The patients in the experimental group were treated with dexamethasone 5mg paronosetron 0.25mg, and the experimental group was treated with Huazhi and Weiyin on the basis of the control group. The patients were treated with cisplatin chemotherapy combined with Huashi and Weiyin combined with western medicine, and the related TCM and FLIE scores of nausea and vomiting within one week of treatment with western medicine alone. Dehumidification and stomach drink by Kunshan traditional Chinese Medicine Hospital decoction unit unified concentrated, divided into 2 oral, in the morning and evening 100 ml. The chemotherapy regimen of western medicine included 135~175mg/m2 (paclitaxel 135~175mg/m2 cisplatin 75mg/m2) DP (docetaxel 75mg/m2 cisplatin 75mg/m2) GP (gemcitabine 1000mg/m2 cisplatin 75mg/m2) NP (vinorelbine 25-30mg/m2 cisplatin 75mg/m2) and gemcitabine 1000mg/m2 cisplatin 75mg/m2 dexamethasone 20mg. It was supplemented with liver protection (150mg intravenous drip) and stomach protection (pam Tora 40mg intravenous drip). By observing clinical indexes (blood routine, liver and kidney function), TCM score of nausea and vomiting and FLIE score of nausea and vomiting, the correlation scores of the first, third, fifth and seventh days of chemotherapy were observed respectively. To evaluate the curative effect of Huashi and Weiyin combined with western medicine in treating nausea and vomiting with dampness resistance and middle scorch after chemotherapy with cisplatin. Statistical method: the data were processed by SPSS statistical analysis software, the two groups were compared and analyzed, the qualitative data were analyzed by x2 test. The quantitative data were consistent with normal distribution by t test. The test statistics and their corresponding P values are given, with P 鈮，

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