【摘要】：目的探討旋復花代赭石湯聯(lián)合甲氧氯普胺和氟哌啶醇對腫瘤惡病質(zhì)惡心嘔吐的效果。方法采用前瞻性隨機對照試驗,將286例腫瘤惡病質(zhì)惡心嘔吐患者隨機分為甲旋二聯(lián)組(n=73)、甲氟二聯(lián)組(n=75)、甲氟旋三聯(lián)組(n=68)和對照組(甲氧氯普胺組,n=70)。采用WHO抗癌藥副作用惡心嘔吐分級標準、惡心嘔吐及干嘔指數(shù)評價量表(INVR)和多維度疲乏癥狀量表-簡表(MFSI-SF)分別對患者用藥前、2周、8周進行跟蹤測評。結(jié)果三聯(lián)組在用藥2、8周時止吐作用有效率分別為76.5%和94.1%,顯著高于對照組和二聯(lián)組(P0.05);三聯(lián)組在用藥2周時INVR評分顯著低于對照組和甲旋二聯(lián)組(P0.05),但與甲氟二聯(lián)組無統(tǒng)計學差異;三聯(lián)組在用藥8周時INVR和MFSI-SF評分均顯著低于對照組和二聯(lián)組(P0.05)。結(jié)論旋復花代赭石湯聯(lián)合西藥三聯(lián)用藥方案對腫瘤惡病質(zhì)惡心嘔吐患者,顯示了長期穩(wěn)定的止吐效果,且能有效改善患者疲乏,值得臨床推廣。
[Abstract]:Objective to investigate the effect of Xinfen Huadai Zhe Shi decoction combined with metoclopramide and haloperidol on the nausea and vomiting of tumor cachexia. Methods in a prospective randomized controlled trial, 286 patients with nausea and vomiting of cachexia were randomly divided into three groups: medroxine group (n = 73), meflurane group (n = 75), trimeflurane group (n = 68) and control group (n = 70). WHO, (INVR) and MFSI-SF were used to measure the adverse effects, nausea and vomiting. The patients were followed up for 2 weeks and 8 weeks before treatment. Results the effective rate of antiemetic effect in the triple group was 76.5% and 94.1% respectively, which was significantly higher than that in the control group and the combined group (P0.05), and the INVR score in the triple group was significantly lower than that in the control group and the methyl-circumflex group at 2 weeks (P0.05), but there was no significant difference between the triple group and the meflorine group. The scores of INVR and MFSI-SF in the triple group were significantly lower than those in the control group and the second group at 8 weeks (P0.05). Conclusion Xinfu Huadai Zhe Shi decoction combined with western medicine has a long-term and stable antiemetic effect on patients with cachexia, and it can effectively improve the fatigue of patients. It is worth popularizing in clinic.
【作者單位】： 鄭州市第九人民醫(yī)院姑息(緩和)治療暨安寧療護中心;鄭州市第一人民醫(yī)院;鄭州大學護理學院;鄭州大學第一附屬醫(yī)院;河南省人民醫(yī)院;
【基金】：河南省科技廳重點科技攻關項目(142102310140) 河南省醫(yī)學科技攻關計劃(201204139) 河南省青年衛(wèi)生科技創(chuàng)新人才項目 河南省鄭州市科技攻關項目(2PPTSF302);河南省鄭州市科技攻關項目(20120821) 河南省鄭州市衛(wèi)生局2011博士創(chuàng)業(yè)基金項目
【分類號】：R730.5

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