中藥注射液聯(lián)合含奧沙利鉑化療方案治療大腸癌的網(wǎng)狀Meta分析
發(fā)布時間：2018-07-28 17:17
【摘要】：目的:采用網(wǎng)狀Meta分析評價中藥注射液(CMI)聯(lián)合含奧沙利鉑(L-OHP)化療方案治療大腸癌的療效和安全性,為臨床提供循證參考。方法:計算機檢索相關(guān)期刊論文,萬方數(shù)據(jù)庫,中國生物醫(yī)學(xué)文獻數(shù)據(jù)庫,中文科技期刊數(shù)據(jù)庫,Pub Med,Embase(各數(shù)據(jù)庫建庫起至2016年11月20日),收集中藥注射液聯(lián)合含L-OHP化療方案對比單純含L-OHP化療方案治療大腸癌的隨機對照試驗(RCT),提取資料并依據(jù)改良的Jadad量表進行質(zhì)量評價后,采用ADDIS軟件進行網(wǎng)狀Meta分析。結(jié)果:最終納入14種CMI,64項RCTs,合計5 081例患者。納入文獻有4篇高質(zhì)量。網(wǎng)狀Meta分析結(jié)果顯示:(1)對比單純化療,3種CMI聯(lián)合含L-OHP的化療方案能提高臨床有效率(WHO標準),7種CMI能提高患者生活質(zhì)量、降低白細胞減少,6種CMI能減少惡心嘔吐,4種CMI能減少周圍神經(jīng)毒性,差異有統(tǒng)計學(xué)意義;(2)在降低周圍神經(jīng)毒性方面,黃芪注射液優(yōu)于艾迪注射液,參麥注射液優(yōu)于復(fù)方苦參注射液、康艾注射液,差異有統(tǒng)計學(xué)意義,其余兩兩之間的對比差異無統(tǒng)計學(xué)意義。結(jié)論:目前證據(jù)支持中藥注射液聯(lián)合含L-OHP化療方案治療大腸癌優(yōu)于單純化療。受納入文獻方法學(xué)質(zhì)量限制,該研究有待大樣本及更多高質(zhì)量的RCT進一步驗證。
[Abstract]:Objective: to evaluate the efficacy and safety of traditional Chinese medicine injection (CMI) combined with oxaliplatin (L-OHP) in the treatment of colorectal cancer by reticular Meta analysis. Methods: the full text database of Chinese periodicals, the database of Wanfang and the database of Chinese biomedical literature were searched by computer. The Chinese sci-tech journal database Pub Medembase (each database was established until November 20, 2016) was used to collect the data of (RCT), extracted from Chinese medicine injection combined with chemotherapy regimen containing L-OHP in the randomized controlled trial of treatment of colorectal cancer compared with the chemotherapy regimen containing L-OHP alone. According to the quality evaluation of the modified Jadad scale, ADDIS software was used to analyze the mesh Meta. Results: 64 items of RCTs of 14 CMIs were included, totally 5081 patients. Four articles of high quality were included in the literature. The results of reticular Meta analysis showed that: (1) the clinical effective rate (WHO standard) and 7 kinds of CMI could improve the quality of life (QOL) of the patients compared with the chemotherapy regimen of 3 CMI and L-OHP alone. Six kinds of CMI can reduce nausea and vomiting and 4 kinds of CMI can reduce peripheral nerve toxicity. (2) Astragalus injection is better than Aidi injection in reducing peripheral neurotoxicity. Shenmai injection was superior to compound Sophora flavescens injection and Kangai injection, the difference was statistically significant. Conclusion: the evidence supports that the combination of traditional Chinese medicine injection and L-OHP regimen is superior to chemotherapy alone in the treatment of colorectal cancer. Limited by the quality of methodology included in the literature, this study needs to be further validated by large samples and more high quality RCT.
【作者單位】： 廣州中醫(yī)藥大學(xué)第四臨床醫(yī)學(xué)院深圳市中醫(yī)院;
【基金】：深圳市科技計劃項目(JCYJ20150401163247231)
【分類號】：R735.34
本文編號：2151016
[Abstract]:Objective: to evaluate the efficacy and safety of traditional Chinese medicine injection (CMI) combined with oxaliplatin (L-OHP) in the treatment of colorectal cancer by reticular Meta analysis. Methods: the full text database of Chinese periodicals, the database of Wanfang and the database of Chinese biomedical literature were searched by computer. The Chinese sci-tech journal database Pub Medembase (each database was established until November 20, 2016) was used to collect the data of (RCT), extracted from Chinese medicine injection combined with chemotherapy regimen containing L-OHP in the randomized controlled trial of treatment of colorectal cancer compared with the chemotherapy regimen containing L-OHP alone. According to the quality evaluation of the modified Jadad scale, ADDIS software was used to analyze the mesh Meta. Results: 64 items of RCTs of 14 CMIs were included, totally 5081 patients. Four articles of high quality were included in the literature. The results of reticular Meta analysis showed that: (1) the clinical effective rate (WHO standard) and 7 kinds of CMI could improve the quality of life (QOL) of the patients compared with the chemotherapy regimen of 3 CMI and L-OHP alone. Six kinds of CMI can reduce nausea and vomiting and 4 kinds of CMI can reduce peripheral nerve toxicity. (2) Astragalus injection is better than Aidi injection in reducing peripheral neurotoxicity. Shenmai injection was superior to compound Sophora flavescens injection and Kangai injection, the difference was statistically significant. Conclusion: the evidence supports that the combination of traditional Chinese medicine injection and L-OHP regimen is superior to chemotherapy alone in the treatment of colorectal cancer. Limited by the quality of methodology included in the literature, this study needs to be further validated by large samples and more high quality RCT.
【作者單位】： 廣州中醫(yī)藥大學(xué)第四臨床醫(yī)學(xué)院深圳市中醫(yī)院;
【基金】：深圳市科技計劃項目(JCYJ20150401163247231)
【分類號】：R735.34
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