【摘要】：白細胞介素17F(interleukin-17F,IL-17F)是主要由Th17細胞分泌的促炎癥因子,屬于IL-17家族,與家族另一成員IL-17A有極強的同源性。IL-17F具有獨特的生物學功能,可誘導多種趨化因子和細胞因子的表達,參與免疫細胞應答及炎癥反應,在發(fā)揮抑制腫瘤細胞進展的同時亦有促進腫瘤進展和轉移的風險。本文對IL-17F的生物學功能、抑瘤效應及促瘤效應等方面的研究進展和取得的新成果進行了綜述,為IL-17F在相關腫瘤治療方面提供依據(jù)。
[Abstract]:Interleukin 17F (interleukin-17F, IL-17F), a proinflammatory factor secreted mainly by Th17 cells, belongs to the IL-17 family and has a very strong homologous.IL-17F with another member of the family member IL-17A. It has a unique biological function, which can induce a variety of chemokines and cytokines, participate in immune response and inflammation, and play an inhibitory role. The development of tumor cells also has the risk of promoting tumor progression and metastasis. This article reviews the progress and new achievements of the biological function, tumor suppressor effect and tumor promoting effect of IL-17F, which provides the basis for IL-17F in the treatment of tumor.
【作者單位】： 十堰市太和醫(yī)院(湖北醫(yī)藥學院附屬醫(yī)院)呼吸內科;
【分類號】：R73-3

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1 王浩;IL-17F在胃癌組織中的表達及其對胃癌細胞生物學特性的影響[D];河北醫(yī)科大學;2015年

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本文編號：2120438