本文選題：中醫(yī) + 放射性腸炎　； 參考：《遼寧中醫(yī)藥大學(xué)》2015年碩士論文

【摘要】：目的:對中醫(yī)治療放射性腸炎的RCT文獻(xiàn)進(jìn)行Meta分析,評價(jià)中醫(yī)對放射性腸炎的治療效果,探討其臨床價(jià)值。方法:計(jì)算機(jī)檢索中文數(shù)據(jù)庫包括相關(guān)期刊論文、萬方數(shù)據(jù)庫、維普中文科技期刊數(shù)據(jù)庫和中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫,外文數(shù)據(jù)庫以Pub Med為主;手工檢索計(jì)算機(jī)數(shù)據(jù)庫尚未錄入的近期發(fā)表的文獻(xiàn);對計(jì)算機(jī)及手工檢索到文獻(xiàn)的參考文獻(xiàn)進(jìn)一步檢索。采用Stata12.0軟件對符合納入標(biāo)準(zhǔn)的文獻(xiàn)進(jìn)行Meta分析。以中醫(yī)治療放射性腸炎的有效率、治療后放射性腸炎患者癥狀評分、生活質(zhì)量評分的改善情況以及腸鏡下腸粘膜的變化情況為評價(jià)指標(biāo)。結(jié)果:1.本研究納入15篇文獻(xiàn)共1363例患者,均為中文文獻(xiàn),文獻(xiàn)質(zhì)量評價(jià)不高。2.Meta分析結(jié)果:(1)在中醫(yī)治療放射性腸炎的有效率方面,中醫(yī)治療組與西藥對照組相比差異有統(tǒng)計(jì)學(xué)意義(P0.05),OR=2.86(95%CI:2.18,3.74)。(2)在改善放射性腸炎患者癥狀(腹痛、腹瀉、粘液膿血便、乏力)評分方面,治療組優(yōu)于對照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),合并效應(yīng)量分別為:SMD(95%CI):0.745(0.541,0.948),SMD(95%CI):0.756(0.552,0.959),SMD(95%CI):0.768(0.443,1.092),SMD(95%CI):0.834(0.586,1.081)。(3)在腸鏡下腸粘膜改善方面,治療組較對照組可提高其有效率,差異有統(tǒng)計(jì)學(xué)意義(P0.05),OR=3.281(95%CI:1.868,5.761)。(4)在改善Karnofsky行為狀態(tài)評分(KPS)方面,治療組優(yōu)于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05),SMD=1.096(95%CI:0.788,1.403)。結(jié)論:1中醫(yī)療法可提高放射性腸炎治療的有效率,對改善患者腹痛、腹瀉、粘液膿血便以及乏力等癥狀有較好療效,并能促進(jìn)腸鏡下腸粘膜病變結(jié)局的良好轉(zhuǎn)化,提高患者的生活質(zhì)量。2清熱利濕法在放射性腸炎的中醫(yī)治療中應(yīng)用頻率較高、療效好,可從濕、熱、毒、瘀、虛等方面進(jìn)行辨證論治。3中醫(yī)療法在放射性腸炎治療方面有一定應(yīng)用價(jià)值,值得臨床進(jìn)一步推廣應(yīng)用,尚需進(jìn)一步結(jié)合循證醫(yī)學(xué)方法探究放射性腸炎最佳的中醫(yī)治療方法。
[Abstract]:Objective: to analyze the RCT literature of Chinese medicine for the treatment of radioactive enteritis by Meta, to evaluate the therapeutic effect of traditional Chinese medicine on radiological enteritis, and to discuss its clinical value. The database is based on Pub Med; manually retrieving the recent published literature that has not been recorded by the computer database; further retrieval of the reference documents of the computer and the manual retrieval. The Stata12.0 software is used for the Meta analysis of the documents which conform to the standard. The effective treatment of radiative enteritis with Chinese medicine and the treatment of postoperative radioactive enteritis The symptom score, the improvement of quality of life score and the changes of intestinal mucosa under the enteroscopy were evaluated. Results: 1. the 15 literature included 1363 patients, all of which were Chinese literature, and the quality evaluation of the literature was not high.2.Meta analysis results: (1) in the treatment of radiation enteritis in traditional Chinese medicine, the treatment group of Chinese medicine and Western Medicine The differences were statistically significant (P0.05), OR=2.86 (95%CI:2.18,3.74). (2) in improving the symptoms of patients with radiation enteritis (abdominal pain, diarrhea, mucous pus and stool, fatigue) scores, the treatment group was better than the control group, the difference was statistically significant (P0.05): SMD (95%CI): 0.745 (0.541,0.948), SMD (95%CI): 0.756 (0.552,0.). 959), SMD (95%CI): 0.768 (0.443,1.092), SMD (95%CI): 0.834 (0.586,1.081). (3) the improvement of intestinal mucosa in the enteroscope, the treatment group can improve its efficiency compared with the control group, the difference is statistically significant (P0.05), OR=3.281 (95%CI:1.868,5.761). (4) in the improvement of Karnofsky behavior status score (KPS), the treatment group is better than the control group, the difference is statistically significant Significance (P0.05), SMD=1.096 (95%CI:0.788,1.403). Conclusion: 1 Chinese medicine therapy can improve the efficiency of radiation enteritis treatment, improve the patient's abdominal pain, diarrhea, mucus pus and stool and fatigue and other symptoms, and promote the good transformation of the outcome of intestinal mucosal lesion under the enteroscopy, improve the quality of life of the patients.2 clearing heat and wet method in radiation The traditional Chinese medicine treatment of enteritis has high frequency and good curative effect. It can be applied in the treatment of radioactive enteritis from the aspects of damp, heat, poison, stasis and deficiency. It has certain applied value in the treatment of radioactive enteritis. It is worth further popularization and application. It is still necessary to further combine the methods of evidence-based medicine to explore the best methods of Chinese medicine for radioenteritis.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R730.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 許玲,施俊,肖艷;“托”法治療放射性腸炎[J];浙江中醫(yī)學(xué)院學(xué)報(bào);2002年06期

2 竇艷;劉慶森;楊云生;孟江云;;氬離子凝固術(shù)對兔大腸黏膜的損傷作用[J];世界華人消化雜志;2009年08期

，

本文編號：2116370