本文選題：喉鱗狀細(xì)胞癌 + Survivin�。� 參考：《臨床耳鼻咽喉頭頸外科雜志》2017年10期

【摘要】：目的:探討Survivin和Aurora-b在喉癌組織中表達(dá)的意義及與其臨床病理特征間的聯(lián)系。探討Survivin和Aurora-b的表達(dá)水平是否具有喉癌生物學(xué)標(biāo)志物的研究價值,以及能否作為喉癌術(shù)后預(yù)測總生存率的預(yù)后指標(biāo)。方法:收集經(jīng)病理科確診的喉癌組織標(biāo)本86例,同時選取癌旁組織86例和正常組織22例作為對照。采用免疫組織化學(xué)法檢測Survivin和Aurora-b在喉癌和癌旁及正常組織中的表達(dá)情況。結(jié)果:Survivin和Aurora-b在喉癌組織中的陽性表達(dá)率明顯高于癌旁及正常組織,其差異有統(tǒng)計學(xué)意義(P0.01)。Survivin蛋白的表達(dá)與淋巴結(jié)轉(zhuǎn)移、復(fù)發(fā)情況等臨床病理特征有相關(guān)性(P0.05),而與年齡、性別、臨床分期及分化情況等病理特征無相關(guān)性。Aurora-b的表達(dá)與臨床分期、復(fù)發(fā)情況等臨床病理特征有相關(guān)性(P0.05),但與年齡、性別、分化情況及淋巴結(jié)轉(zhuǎn)移等病理特征無相關(guān)性。生存曲線顯示陰性組生存期都比陽性組高,提示Survivin和Aurora-b在喉癌中表達(dá)水平具有提示預(yù)后的意義,且均為負(fù)性預(yù)后因子。COX回歸分析結(jié)果顯示,喉癌患者術(shù)后Aurora-b表達(dá)和復(fù)發(fā)情況為影響預(yù)后的獨立危險因素(P0.05);而Survivin表達(dá)和淋巴結(jié)轉(zhuǎn)移情況則不是影響預(yù)后的獨立危險因素。結(jié)論:本研究表明Survivin和Aurora-b以及兩者的協(xié)同作用可能在喉癌的發(fā)生、發(fā)展、轉(zhuǎn)移和預(yù)后等方面扮演重要角色,其表達(dá)水平與腫瘤的惡性程度和侵襲性正相關(guān),可能是預(yù)后不良的提示指征,在診療過程中具有預(yù)測預(yù)后的潛在研究價值。
[Abstract]:Objective: to investigate the expression of survivin and Aurora-b in laryngeal carcinoma and its relationship with clinicopathological features. To explore whether the expression of survivin and Aurora-b is valuable in the study of biological markers of laryngeal carcinoma and whether it can be used as a prognostic index to predict the overall survival rate after laryngeal cancer operation. Methods: 86 cases of laryngeal carcinoma were collected, 86 cases of paracancerous tissue and 22 cases of normal tissue were selected as control group. The expression of survivin and Aurora-b in laryngeal carcinoma and adjacent and normal tissues was detected by immunohistochemical method. Results the positive expression rate of survivin and Aurora-b in laryngeal carcinoma tissues was significantly higher than that in adjacent and normal tissues. The difference was statistically significant (P0.01) .survivin protein expression was correlated with clinicopathological features such as lymph node metastasis and recurrence (P0.05), but it was associated with age and sex. There was no correlation between the expression of Aurora-b and clinical stage and recurrence (P0.05), but there was no correlation with age, sex, differentiation and lymph node metastasis. Survival curve showed that the survival time of the negative group was longer than that of the positive group, suggesting that the expression of survivin and Aurora-b in laryngeal carcinoma had prognostic significance, and both of them were negative prognostic factors. Cox regression analysis showed that survivin and Aurora-b were negative prognostic factors. The expression and recurrence of Aurora-b were independent prognostic factors in laryngeal cancer patients (P0.05), while survivin expression and lymph node metastasis were not independent prognostic factors. Conclusion: this study suggests that survivin, Aurora-b and their synergistic effects may play an important role in the occurrence, development, metastasis and prognosis of laryngeal carcinoma. The expression level of survivin and Aurora-b is positively correlated with the malignancy and invasiveness of the tumor. It may be an indication of poor prognosis and has potential research value in predicting prognosis in the course of diagnosis and treatment.
【作者單位】： 桂林醫(yī)學(xué)院;桂林醫(yī)學(xué)院附屬醫(yī)院耳鼻咽喉頭頸外科;桂林醫(yī)學(xué)院附屬醫(yī)院耳鼻咽喉頭頸外科研究所;桂林醫(yī)學(xué)院附屬醫(yī)院病理科;
【基金】：基金項目:人口健康安全技術(shù)開發(fā)與應(yīng)用研究(No:2016012706-4)
【分類號】：R739.6

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本文編號：2084975