本文選題：肝腫瘤 + 微囊藻毒素類��； 參考：《中國全科醫(yī)學(xué)》2017年11期

【摘要】：目的探討廣西地區(qū)原發(fā)性肝癌患者血清微囊藻毒素-LR(MC-LR)的水平及其相關(guān)影響因素。方法選取2014年12月—2016年6月廣西醫(yī)科大學(xué)附屬腫瘤醫(yī)院收治的來自廣西地區(qū)的144例原發(fā)性肝癌患者作為肝癌組,另選取同期本院體檢健康者158例作為對照組。調(diào)查兩組一般人口學(xué)特征、日常生活方式、飲食習(xí)慣等,并采集靜脈血,采用酶聯(lián)免疫吸附法(ELISA)檢測血清乙型肝炎病毒(HBV)感染標(biāo)志物,包括乙型肝炎表面抗原(HBsAg)、乙型肝炎表面抗體(HBsAb)、乙型肝炎核心抗體(HBcAb)、乙型肝炎e抗原(HBeAg)、乙型肝炎e抗體(HBeAb),以及MC-LR水平和谷胱甘肽(GSH)含量。結(jié)果肝癌組血清MC-LR水平為(0.078±0.039)μg/L,高于對照組的(0.061±0.041)μg/L(t=3.351,P0.01)。肝癌組和對照組中不同性別、年齡、民族、HBsAg陽性、吸煙、飲酒情況者血清MC-LR水平比較,差異均無統(tǒng)計學(xué)意義(P0.05);對照組中不同HBV感染者血清MC-LR水平比較,差異無統(tǒng)計學(xué)意義(P0.05);肝癌組和對照組中不同食魚生、溝塘水飲用史者血清MC-LR水平比較,差異均有統(tǒng)計學(xué)意義(P0.05)。肝癌組GSH含量為(9.1±5.1)μg/L,低于對照組的(15.2±8.1)μg/L(t=-6.899,P0.001)。按照對照組血清MC-LR的中位數(shù)(0.042μg/L)進(jìn)行暴露程度分層,肝癌組低暴露和高暴露人群GSH含量比較,差異無統(tǒng)計學(xué)意義(t=-1.290,P=0.200);對照組低暴露人群GSH含量高于高暴露人群(t=2.090,P=0.038)。結(jié)論廣西地區(qū)原發(fā)性肝癌患者血清MC-LR水平高于健康人群,GSH含量低于健康人群。MC-LR高暴露的健康人群血清GSH含量低于MC-LR低暴露人群。食用魚生、長期飲用溝塘水可升高血清MC-LR水平。
[Abstract]:Objective to investigate the level of serum microcystin -LR (MC-LR) and its related factors in the patients with primary liver cancer in Guangxi, and to select 144 cases of primary liver cancer from the Affiliated Cancer Hospital of Guangxi Medical University from December 2014 to June 2016 as the liver cancer group, and to select 158 healthy persons in the same period of the hospital. As a control group, the two groups of general demographic characteristics, daily lifestyle, dietary habits, and venous blood were collected, and enzyme linked immunosorbent assay (ELISA) was used to detect the serum hepatitis B virus (HBV) infection markers, including hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B core antibody (HBcAb), and B Hepatitis e antigen (HBeAg), hepatitis B e antibody (HBeAb), and MC-LR level and glutathione (GSH) content. The serum MC-LR level of liver cancer group was (0.078 + 0.039) mu g/L, higher than that of the control group (0.061 + 0.041) mu g/L (t=3.351, P0.01). The serum levels of different sex, age, nationality, HBsAg positive, smoking and drinking alcohol in the liver cancer group and the control group were in the liver cancer group and the control group. The difference was not statistically significant (P0.05), and there was no significant difference in serum MC-LR level in the control group (P0.05), and the difference in serum MC-LR level between the liver cancer group and the control group was statistically significant (P0.05). The GSH content of the liver cancer group was (9.1 + 5.1) mu g/L, lower than that of the control group. (15.2 + 8.1) mu g/L (t=-6.899, P0.001). The exposure level was stratified according to the median of MC-LR in the control group (0.042 mu g/L). The difference of GSH content in the low exposure and high exposure group of the liver cancer group was not statistically significant (t=-1.290, P=0.200), and the content of GSH in the low exposed population in the control group was higher than that of the high exposure group (t=2.090, P=0.038). Conclusion Guangxi The level of serum MC-LR in the patients with primary liver cancer was higher than that of the healthy people. The content of GSH in the healthy people with high exposure to.MC-LR was lower than that in the healthy population. The serum GSH content was lower than that of the MC-LR low exposure population.
【作者單位】： 廣西醫(yī)科大學(xué)公共衛(wèi)生學(xué)院環(huán)境衛(wèi)生學(xué)教研室;廣西高校高發(fā)疾病預(yù)防與控制研究重點(diǎn)實(shí)驗(yàn)室;廣西醫(yī)科大學(xué)附屬腫瘤醫(yī)院檢驗(yàn)科;
【基金】：國家自然科學(xué)基金資助項目(81360420,81660529) 廣西自然科學(xué)基金資助項目(2015GXNSFAA139120)
【分類號】：R735.7

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