本文選題：紡錘體與動(dòng)粒相關(guān)復(fù)合物 + miRNA�。� 參考：《中國(guó)生物化學(xué)與分子生物學(xué)報(bào)》2017年03期

【摘要】：紡錘體與動(dòng)粒相關(guān)復(fù)合物2(spindle and kinetochore associated 2,SKA2)是參與維持有絲分裂中期赤道板的穩(wěn)定和適時(shí)關(guān)閉紡錘體檢測(cè)點(diǎn)的重要蛋白質(zhì)。早期研究發(fā)現(xiàn),SKA2不僅調(diào)控細(xì)胞周期的進(jìn)程而影響細(xì)胞增殖,還能通過其他分子機(jī)制參于腫瘤的發(fā)生。微小RNA(microRNA,miRNA)作為原癌基因或抑癌基因影響腫瘤細(xì)胞的增殖和遷移。新近研究顯示,SKA2在其內(nèi)含子區(qū)域miRNA的調(diào)節(jié)下,在一些腫瘤組織和細(xì)胞中異常高表達(dá)。由此可見,SKA2和miRNA之間存在密切聯(lián)系。本文結(jié)合目前的研究成果,對(duì)SKA2與相關(guān)的miRNA在腫瘤發(fā)生發(fā)展中的作用及其分子機(jī)制作一綜述。
[Abstract]:Spindle and motility associated complex (2(spindle and kinetochore associated _ 2 / SKA _ 2) is an important protein involved in maintaining the stability of the equatorial plate in the metaphase of mitosis and closing the detection point of the spindle at the right time. Early studies have found that SKA2 not only regulates cell cycle progression and affects cell proliferation, but also participates in tumorigenesis through other molecular mechanisms. MicroRNAs miRNAs as proto-oncogenes or tumor suppressor genes affect the proliferation and migration of tumor cells. Recent studies have shown that SKA2 is overexpressed in some tumor tissues and cells under the regulation of miRNA in its intron region. Therefore, there is a close relationship between SKA2 and miRNA. In this paper, the role and molecular mechanism of SKA2 and miRNA in tumorigenesis and development are reviewed.
【作者單位】： 寧波大學(xué)醫(yī)學(xué)院浙江省病理生理學(xué)技術(shù)研究重點(diǎn)實(shí)驗(yàn)室;寧波第二醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金(No.81372209) 華美基金(No.2016HMKY35)資助~~
【分類號(hào)】：R730.2
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本文編號(hào)：2013989