本文選題：血管內(nèi)皮瘤 + 肝　； 參考：《臨床與實(shí)驗(yàn)病理學(xué)雜志》2017年03期

【摘要】：目的 探討實(shí)質(zhì)臟器上皮樣血管內(nèi)皮瘤(epihelioid hemangioendothelioma,EHE)的臨床病理學(xué)特征、免疫表型、診斷及鑒別診斷。方法 回顧性分析12例手術(shù)切除及粗針穿刺活檢診斷為EHE的臨床病理學(xué)特征及免疫表型,并進(jìn)行隨訪。結(jié)果男性9例,女性3例,患者年齡30~69歲,平均43.5歲。其中肝臟8例,骨組織3例,肺組織1例。鏡檢:圓形及卵圓形上皮樣細(xì)胞為散在單個(gè)、巢團(tuán)狀、條索狀排列,瘤細(xì)胞胞質(zhì)嗜酸性,可見細(xì)胞質(zhì)內(nèi)空泡及散在紅細(xì)胞,間質(zhì)黏液樣變性,有些病例可見散在少數(shù)鈣化。免疫表型:CD34、CD31、FⅧRAg均呈陽性,多數(shù)病例均帶瘤存活,1例患者術(shù)后半年復(fù)發(fā),1例患者隨訪100個(gè)月后死亡,3例患者失訪。結(jié)論 EHE屬于少見的血管源性低度惡性腫瘤,尤其發(fā)生于實(shí)質(zhì)臟器者,臨床及影像學(xué)特征無特異性,確診需結(jié)合組織病理學(xué)、免疫表型或分子生物學(xué)檢查WWTR1-CAMTA1融合基因。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of epihelioid hemangioendothelioma (EHEs) in parenchymal organs. Methods the clinicopathological features and immunophenotype of 12 cases of EHE diagnosed by surgical resection and coarse needle biopsy were retrospectively analyzed and followed up. Results there were 9 males and 3 females with an average age of 43.5 years (30 ~ 69 years). There were 8 cases of liver, 3 cases of bone tissue and 1 case of lung tissue. Microscopic examination: round and oval epithelioid cells were scattered in a single, nesting, striped arrangement, tumor cell cytoplasm eosinophilic, cytosolic vacuoles and scattered red blood cells, interstitial myxoid degeneration, some cases scattered in a few calcification. The immunophenotype of CD34, CD31 and F 鈪，

本文編號：1969681