本文選題：Bad蛋白 + 前列腺癌��； 參考：《延邊大學(xué)》2017年碩士論文

【摘要】：目的:探討B(tài)ad蛋白在前列腺癌(PCa)中的表達(dá)及其臨床意義。方法:選擇48例前列腺癌(PCa)、21例前列腺上皮內(nèi)瘤(PIN)和48例癌旁良性前列腺組織(BPH),采用免疫組織化學(xué)染色法觀察Bad蛋白在前列腺上皮及間質(zhì)細(xì)胞中的表達(dá),采用化學(xué)發(fā)光法檢測(cè)全部患者血清中的PSA的值,分析Bad表達(dá)與PCa臨床病理特征的關(guān)系及與不同PSA的值的相關(guān)性。結(jié)果:1)Bad蛋白在PCa和PIN的上皮細(xì)胞中表達(dá)率分別為85.4%和66.7%,高于癌旁BPH中的表達(dá)33.3%,差異有統(tǒng)計(jì)學(xué)意義(均P0.01);2)Bad蛋白在Pca旁間質(zhì)細(xì)胞中表達(dá)率為52.1%,在BPH間質(zhì)中呈弱陽(yáng)(25.0%)或陰性表達(dá),有統(tǒng)計(jì)學(xué)差異(P0.05);3)Bad蛋白在Gleason評(píng)分≤7和7的PCa中表達(dá)率分別是66.7%和92.6%,有統(tǒng)計(jì)學(xué)差異(P0.05);4)血清不同PSA值與(10ng/ml、10-20ng/ml、20ng/ml)與其對(duì)應(yīng)的 Bad 陽(yáng)性表達(dá)率(76%、85%和89%)均無明顯相關(guān)性(均P0.05)。結(jié)論:在PCa組織中Bad蛋白的表達(dá)率高,并與PCa的Gleason評(píng)分有關(guān),提示Bad蛋白在PCa的發(fā)生、發(fā)展過程中發(fā)揮重要作用,有望成為PCa預(yù)測(cè)的預(yù)后指標(biāo)之一。
[Abstract]:Objective: to investigate the expression and clinical significance of Bad protein in prostate cancer. Methods: the expression of Bad protein in prostatic epithelium and stromal cells was observed by immunohistochemical staining in 48 cases of prostatic carcinoma and 21 cases of prostatic intraepithelial neoplasia (PIN) and 48 cases of benign prostatic tissue adjacent to carcinoma. Chemiluminescence assay was used to detect the value of PSA in serum of all patients. The relationship between the expression of Bad and the clinicopathological characteristics of PCa and the correlation between the expression of Bad and the values of different PSA were analyzed. Results the expression rate of Bad protein in PCa and PIN was 85.4% and 66.7%, respectively, which was higher than that in BPH adjacent to cancer. The difference was statistically significant (the expression rate of Bad protein was 52.1% in Pca stromal cells, and that in BPH stroma was 25.0%) or negative. There was statistical difference in the expression rate of P0.05 ~ (3) Bad protein in PCa with Gleason scores 鈮，

本文編號(hào)：1966110