本文選題：吉西他濱 + 多西他賽��； 參考：《基因組學(xué)與應(yīng)用生物學(xué)》2017年03期

【摘要】：本研究報(bào)告了吉西他濱聯(lián)合多西他賽化療引起尿失禁的一例臨床案例。我們運(yùn)用Naranjo's評(píng)估量表分析了吉西他濱聯(lián)合多西他賽化療與尿失禁不良反應(yīng)之間的相關(guān)性及緊密程度。分析了關(guān)于吉西他濱聯(lián)合多西他賽化療藥品不良反應(yīng),闡述了吉西他濱聯(lián)合多西他賽化療引起尿失禁的可能機(jī)制。根據(jù)Naranjo's評(píng)估量表評(píng)分總分值為7分,說(shuō)明了吉西他濱聯(lián)合多西他賽化療引起尿失禁的可能性較高,但是吉西他濱聯(lián)合多西他賽化療引起尿失禁的機(jī)制尚不明確,我們推測(cè)可能與多西他賽的神經(jīng)毒性有一定關(guān)系,藥物神經(jīng)毒性引起膀胱與尿道平滑肌功能失調(diào),導(dǎo)致尿失禁。然而,尿失禁的發(fā)病機(jī)制與多種因素有關(guān),因此在臨床上尚需更多病例觀察以明其機(jī)制,從而有效改善相關(guān)藥物不良反應(yīng)的發(fā)生,提高患者的生存質(zhì)量。
[Abstract]:This study reports a case of urinary incontinence caused by gemcitabine combined with docetaxel chemotherapy. We analyzed the correlation and tightness between gemcitabine combined with docetaxel chemotherapy and adverse effects of urinary incontinence using Naranjo's scale. The adverse drug reactions of gemcitabine combined with docetaxel were analyzed and the possible mechanism of urinary incontinence induced by gemcitabine combined with docetaxel was discussed. The total score of Naranjo's evaluation scale is 7, which indicates that gemcitabine combined with docetaxel chemotherapy is more likely to cause urinary incontinence, but the mechanism of gemcitabine combined with docetaxel chemotherapy induced urinary incontinence is not clear. We speculate that it may be related to the neurotoxicity of docetaxel, which results in bladder and urethral smooth muscle dysfunction and urinary incontinence. However, the pathogenesis of urinary incontinence is related to many factors, so it is necessary to observe more cases in clinic in order to improve the occurrence of adverse drug reactions and improve the quality of life of patients.
【作者單位】： 浙江大學(xué)附屬第一醫(yī)院;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(No.81400958)資助
【分類(lèi)號(hào)】：R730.53

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