本文選題：甲狀腺腫瘤 + 癌　； 參考：《中國普通外科雜志》2017年05期

【摘要】：目的:探討多灶性甲狀腺乳頭狀癌(PTC)的臨床病理及頸淋巴結(jié)轉(zhuǎn)移特征。方法:回顧性分析2016年6月—2016年10月于鄭州大學(xué)第一附屬醫(yī)院甲狀腺外科行手術(shù)治療并經(jīng)術(shù)后病理證實(shí)的323例PTC患者的臨床資料,其中多灶性PTC患者148例,單灶性PTC患者175例。結(jié)果:多灶性PTC患者與單灶性PTC患者間性別、年齡、癌灶最大徑差異無統(tǒng)計(jì)學(xué)意義(均P0.05),但前者更易發(fā)生頸部中央?yún)^(qū)淋巴結(jié)轉(zhuǎn)移(P0.001)、頸側(cè)區(qū)淋巴結(jié)轉(zhuǎn)移(P=0.028)及腺外浸潤(P0.001);多灶性PTC患者中,癌灶數(shù)≥3的患者中央?yún)^(qū)淋巴結(jié)轉(zhuǎn)移率(P=0.010)、側(cè)區(qū)淋巴結(jié)轉(zhuǎn)移率(P=0.018)及腺外浸潤的發(fā)生率(P=0.020)明顯高于癌灶數(shù)=2的患者;多因素分析顯示,癌灶最大徑(P=0.005)及癌灶數(shù)量(P=0.006)為多灶性PTC中央?yún)^(qū)淋巴結(jié)轉(zhuǎn)移的獨(dú)立危險(xiǎn)因素。結(jié)論:多灶性PTC較單灶性PTC侵襲性強(qiáng),更易發(fā)生轉(zhuǎn)移、浸潤,建議選擇全甲狀腺切除加中央?yún)^(qū)淋巴結(jié)清掃作為標(biāo)準(zhǔn)化手術(shù)方式,頸側(cè)區(qū)存在可疑腫大淋巴結(jié)者應(yīng)積極行頸側(cè)區(qū)淋巴結(jié)清掃術(shù)。
[Abstract]:Objective: to investigate the clinicopathological and cervical lymph node metastasis of multi-focal papillary thyroid carcinoma (PTC). Methods: the clinical data of 323 patients with PTC who were treated surgically in the first affiliated Hospital of Zhengzhou University from June 2016 to October 2016 and proved by pathology were retrospectively analyzed, including 148 patients with multifocal PTC. 175 patients with single focus PTC. Results: the sex and age of patients with multifocal PTC and single focus PTC were analyzed. There was no significant difference in the maximum diameter of the tumor (all P 0.05, but the former was more likely to develop cervical central lymph node metastasis (P0.001), cervical lateral lymph node metastasis (P0.028) and extraglandular invasion (P0.001). The rate of lymph node metastasis in the central region and lateral region were significantly higher in the patients with tumor number 鈮，

本文編號：1936038