本文選題：癌 + 肝細(xì)胞　； 參考：《腫瘤》2017年01期

【摘要】：目的 :探討抑癌基因環(huán)指蛋白180(ring finger protein 180,RNF180)在肝細(xì)胞癌及癌旁肝硬化組織中的表達(dá)情況及臨床意義。方法 :采用免疫組織化學(xué)法檢測76例肝細(xì)胞癌及其對(duì)應(yīng)癌旁肝硬化組織中RNF180的表達(dá)情況,并分析肝細(xì)胞癌中RNF180的表達(dá)與臨床病理特征及生存期預(yù)后的關(guān)系。結(jié)果 :RNF180在肝癌組織中的陽性表達(dá)率為39.47%(30/76),明顯低于癌旁肝硬化組織中的陽性表達(dá)率86.84(%66/76),差異有統(tǒng)計(jì)學(xué)意義(P=0.006);且肝細(xì)胞癌組織中RNF180的表達(dá)強(qiáng)度明顯低于癌旁肝硬化組織(Z=-2.480,P=0.013)。RNF180的陽性表達(dá)率在AFP≤200μg/L的肝細(xì)胞癌中明顯高于AFP200μg/L的肝細(xì)胞癌組織(P=0.031)。RNF180表達(dá)陰性組患者的平均生存期為(16.42±6.39)個(gè)月,而表達(dá)陽性組為(20.40±5.86)個(gè)月,差異有統(tǒng)計(jì)學(xué)意義(P=0.002)。COX多因素分析結(jié)果提示,有無門靜脈癌栓、腫瘤個(gè)數(shù)和RNF180表達(dá)為影響肝癌患者預(yù)后的獨(dú)立因素。結(jié)論 :抑癌基因RNF180在一定程度上參與了肝細(xì)胞癌的發(fā)生,促進(jìn)了肝細(xì)胞癌的發(fā)展進(jìn)程,RNF180可能成為肝細(xì)胞癌診斷、病情判斷及預(yù)后預(yù)測的新的分子標(biāo)志。
[Abstract]:Objective: to investigate the expression and clinical significance of 180(ring finger protein 180 in hepatocellular carcinoma and paracancerous cirrhosis. Methods: immunohistochemical method was used to detect the expression of RNF180 in 76 cases of hepatocellular carcinoma and its adjacent liver cirrhosis, and to analyze the relationship between the expression of RNF180 and clinicopathological features and prognosis. Results the positive expression rate of RNF180 in hepatocellular carcinoma was 39.4730 / 76, which was significantly lower than that in paracarcinomatous cirrhosis (86.84 f / 76), the difference was statistically significant (P 0.006), and the expression intensity of RNF180 in HCC was significantly lower than that in paracancerous cirrhosis. The positive rate of AFP 鈮，

本文編號(hào)：1935679