本文選題：食管癌 + E-鈣黏蛋白��； 參考：《中國臨床藥理學(xué)雜志》2017年23期

【摘要】：目的探討E-鈣黏蛋白(E-cad)在食管癌組織中的表達(dá)及其與術(shù)后復(fù)發(fā)的相關(guān)性。方法選取2014年10月到2015年10月在本院接受手術(shù)治療并保留有完整腫瘤組織切片的食管癌患者60例,腫瘤組織60例,癌旁正常組織20例。用免疫組化法檢測食管癌組織和正常組織中E-cad的表達(dá)情況。結(jié)果食管鱗癌組織中E-cad陽性表達(dá)率43.33%(26例/60例),明顯低于癌旁正常組織的85.00%(51例/60例),差異有統(tǒng)計學(xué)意義(P0.01)。高、中分化組與低分化組、浸潤深度未達(dá)肌層組與深達(dá)肌層組、淋巴結(jié)組與淋巴結(jié)未轉(zhuǎn)移組之間,E-cad表達(dá)情況差異均有統(tǒng)計學(xué)意義(P0.05或P0.01),腫瘤分期Ⅲ期與≥Ⅲ期之間,E-cad表達(dá)差異無統(tǒng)計學(xué)意義(P0.05)。復(fù)發(fā)組E-cad陽性表達(dá)率為32.00%(8例/25例),低于未復(fù)發(fā)組的51.43%(18例/35例),但差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論 E-cad在食管癌組織中表達(dá)下調(diào),且其表達(dá)與腫瘤分化程度、肌層浸潤深度及淋巴結(jié)是否轉(zhuǎn)移有一定的相關(guān)性,但與術(shù)后復(fù)發(fā)沒有直接關(guān)系。
[Abstract]:Objective to investigate the expression of E-cadn in esophageal carcinoma and its correlation with postoperative recurrence. Methods from October 2014 to October 2015, 60 patients with esophageal cancer, 60 patients with tumor tissue and 20 patients with normal adjacent tissues were selected. Immunohistochemical method was used to detect the expression of E-cad in esophageal carcinoma and normal tissues. Results the positive expression rate of E-cad in esophageal squamous cell carcinoma was 43.33 / 60, which was significantly lower than that in the adjacent normal tissues (55.00 / 60). The difference was statistically significant (P 0.01). High and medium differentiation group and low differentiation group, the infiltration depth did not reach the muscular layer group and the deep reach muscle layer group, The difference of E-cad expression between lymph node group and lymph node non-metastasis group was statistically significant (P0.05 or P0.01). There was no significant difference in E-cad expression between stage 鈪，

本文編號：1916743