本文選題：兒童 + 白血病��； 參考：《鄭州大學(xué)》2015年碩士論文

【摘要】：目的:目前兒童白血病的病因和發(fā)病機(jī)制上尚不清楚,眾多學(xué)者認(rèn)為白血病的發(fā)生是環(huán)境因素和遺傳因素共同作用的結(jié)果。本研究旨在探討兒童白血病發(fā)生的環(huán)境危險(xiǎn)因素,為兒童白血病的防治、病因和發(fā)病機(jī)制提供科學(xué)依據(jù)。方法:采用病例對(duì)照研究方法,于2014年4月至5月在河南省某3家醫(yī)院募集現(xiàn)治的16歲以下白血病患兒168例;同期同醫(yī)院在呼吸、中醫(yī)或康復(fù)病區(qū),募集16歲以下、排除其他腫瘤性疾病、血液性疾病、免疫性疾病的非CL對(duì)照兒童168例進(jìn)入對(duì)照組。采用統(tǒng)一的問卷,以面對(duì)面訪談的方式進(jìn)行調(diào)查。問卷包括一般人口學(xué)特征、患兒相關(guān)危險(xiǎn)因素、母親及父親相關(guān)危險(xiǎn)因素。先對(duì)潛在的影響因素用2c檢驗(yàn)等方法作單因素分析的篩選,后作非條件多因素Logistic回歸分析。結(jié)果:在單因素分析中,兒童常住地、出生體質(zhì)量異常、娩出方式、淋巴/造血系統(tǒng)疾病家族史、住宅低頻電磁場暴露史、住宅周圍污染、X線或CT暴露史、兒童病前有毒有害化學(xué)制劑接觸史、母親文化程度、流產(chǎn)史、母親孕前/孕期有毒有害化學(xué)劑接觸史、父親文化程度、父親孕前X線或CT接觸史和孕前有毒有害化學(xué)制劑接觸史等14個(gè)因素有統(tǒng)計(jì)學(xué)意義(P0.05),其中患兒出生體重異常、淋巴/造血系統(tǒng)疾病家族史、住宅低頻電磁場暴露史、住宅周圍污染、病前有毒有害化學(xué)制劑接觸史、母親孕前/孕期有毒有害化學(xué)制劑接觸史及父親孕前有毒有害化學(xué)制劑接觸史7項(xiàng)因素在多因素Logistic回歸分析中有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:患兒出生體重異常、淋巴/造血系統(tǒng)疾病家族史、住宅低頻電磁場暴露史、住宅周圍污染、病前有毒有害化學(xué)制劑接觸史、母親孕前/孕期有毒有害化學(xué)制劑接觸史及父親孕前有毒有害化學(xué)制劑接觸史可能會(huì)增加兒童白血病的發(fā)病風(fēng)險(xiǎn)。我們通過人為控制減少暴露的環(huán)境危險(xiǎn)因素,降低兒童白血病的發(fā)病率和死亡率。
[Abstract]:Objective: at present, the etiology and pathogenesis of childhood leukemia are not clear, many scholars believe that the occurrence of leukemia is the result of environmental factors and genetic factors. The purpose of this study was to explore the environmental risk factors of childhood leukemia and to provide scientific basis for the prevention, treatment, etiology and pathogenesis of childhood leukemia. Methods: from April to May 2014, 168 children with leukemia under 16 years old were recruited from 3 hospitals in Henan Province, and were recruited under 16 years of age in the same hospital in respiratory, traditional Chinese medicine or rehabilitation area. 168 non-CL control children with other tumour, hematologic and immune diseases were excluded from the control group. A unified questionnaire was used to conduct the investigation in the form of face-to-face interview. The questionnaire included general demographic characteristics, risk factors related to children, mother and father related risk factors. The potential influencing factors were screened by single factor analysis by 2c test, and then by non conditional multivariate Logistic regression analysis. Results: in univariate analysis, there were abnormal birth mass, birth delivery mode, family history of lymphatic / hematopoietic diseases, history of exposure to low-frequency electromagnetic fields in residence, exposure history of X-ray or CT exposure to contamination around residence. History of exposure to toxic and harmful chemicals before illness in children, education of mothers, history of miscarriage, history of exposure of toxic and harmful chemicals to mothers before / during pregnancy, education of fathers, There were 14 factors such as father's exposure history of X-ray or CT before pregnancy and exposure history of toxic and harmful chemicals before pregnancy. There were 14 factors such as abnormal birth weight, family history of lymphoid / hematopoietic diseases, history of exposure to low-frequency electromagnetic fields in residence. There were seven factors including the exposure history of toxic and harmful chemicals before illness, the exposure history of mother before pregnancy / pregnancy and the history of father's exposure to toxic and harmful chemicals before pregnancy. There were significant differences between the seven factors in multivariate Logistic regression analysis (P 0.05). Conclusion: abnormal birth weight, family history of lymphoid / hematopoietic diseases, history of exposure to low frequency electromagnetic fields, pollution around the house, exposure to toxic and harmful chemicals before the disease. The history of exposure to toxic and harmful chemicals in the mother before / during pregnancy and in the father before pregnancy may increase the risk of leukemia in children. We reduce childhood leukemia morbidity and mortality by artificially controlling exposure to environmental risk factors.
【學(xué)位授予單位】：鄭州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R733.7

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相關(guān)期刊論文 前1條

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本文編號(hào)：1893311