本文選題：肺癌 + 云南��； 參考：《昆明醫(yī)科大學(xué)》2017年碩士論文

【摘要】：[目的]通過(guò)分析云南省腫瘤醫(yī)院2012年至2015年首診肺癌患者的基本情況、疾病特征及生存情況,了解云南省肺癌的發(fā)病特點(diǎn),為云南省肺癌防治工作提供理論依據(jù)。[方法]篩選2012年1月1日至2015年7月10日至云南省腫瘤醫(yī)院首診的肺癌患者3859例。首先,進(jìn)行各因素描述性分析;其次,將地區(qū)劃分為宣威、富源地區(qū)(Xuanwei and Fuyuan XF)和非宣威、富源地區(qū)(non-Xuanwei and Fuyuan,non-XF),針對(duì)兩個(gè)不同區(qū)域的各因素進(jìn)行對(duì)比分析;最后,對(duì)各因素進(jìn)行生存分析。[結(jié)果]1.描述性分析整體平均發(fā)病年齡為57.32± 10.86歲;男性2692例(69.8%),女性1167例(30.2%) ; XF患者共788例(20.4%);首發(fā)病灶右肺2195例(57.3%),左肺1634例(42.7%);吸煙患者1888例(48.99%);健康體檢發(fā)現(xiàn)病灶患者285例(7.4%);腺癌 1737 例(45.0%%),鱗癌 948 例(24. 6%),小細(xì)胞癌 439 (11.4%);臨床表現(xiàn)以咳嗽72.8%、咳痰58.9%、痰中帶血27.3%癥狀居多;ⅣV期患者比例最大,占 50.0%。2.對(duì)比分析XF男女比例(1.58: 1),非XF男女比例(2.57: 1) ; XF腺癌比例(64.2%),非XF腺癌比例(40.1%);兩區(qū)域女性均以腺癌為主(非XF女性腺癌占66.1%,XF女性腺癌占81.0%),而XF男性以腺癌為主(53.5%),非XF男性則以鱗癌為主(36.6%) ; XF健康體檢發(fā)現(xiàn)肺部病灶的比例(16.8%)高于非XF (5.0% ;XFⅠ、Ⅱ期患者比例(分別為24.5%、13.0%),非XFⅠ、Ⅱ期患者比例(分別為8.9%、7.1%)。3.生存分析3859例肺癌患者生存分析顯示,365天(1年)、730天(2年)、1000天(2.74年)的生存率分別為59.5%、38.5%、19.0%;多因素COX回歸分析顯示,對(duì)肺癌患者生存預(yù)后有顯著影響的因素包括體重指數(shù)(Body Mess Index, BMI)(相對(duì)危險(xiǎn)度Relative Risk, RR為0.807, P0.001)、地區(qū)(相對(duì)危險(xiǎn)度為0.744,P0.001)、TNM分期(相對(duì)危險(xiǎn)度為1.643, P0.001)、化療(相對(duì)危險(xiǎn)度為0.641, P0.001)、放療(相對(duì)危險(xiǎn)度為0.777, P0.001)、病理類型(相對(duì)危險(xiǎn)度為1.098, P0.001)、體檢(相對(duì)危險(xiǎn)度為0.588, P0.001)、吸煙(相對(duì)危險(xiǎn)度為1.374, P0.001)、ECOG評(píng)分(相對(duì)危險(xiǎn)度為1.144, P=0.004)、年齡(相對(duì)危險(xiǎn)度為1.164, P= 0.003)、民族(相對(duì)危險(xiǎn)度為1.194, P=0.049)。[結(jié)論]1.云南省腫瘤醫(yī)院肺癌首診患者中,男性居多;腺癌為第一病理類型;體檢患者比例較低;XF發(fā)病率高;患者多數(shù)以出現(xiàn)咳嗽、咳痰、痰中帶血癥狀后就診;首診中晚期患者所占比例較高;2.XF男女比例低于非XF; XF腺癌比例高于非XF; XF生存率及臨床早期患者比例較其他地區(qū)高,提示與云南省其他地區(qū)相比,XF人群癌癥篩查和肺癌防范意識(shí)突出,使得該地區(qū)早期診斷和總體生存率較高;3.肺癌患者的生存預(yù)后與BMI、地區(qū)分布、TNM分期、化療、放療、吸煙、體檢、ECOG評(píng)分、病理類型、年齡以及民族有關(guān)。
[Abstract]:[objective] to analyze the basic condition, disease characteristics and survival status of lung cancer patients in Yunnan Cancer Hospital from 2012 to 2015, to understand the incidence characteristics of lung cancer in Yunnan Province, and to provide a theoretical basis for the prevention and treatment of lung cancer in Yunnan Province. Methods: from January 1, 2012 to July 10, 2015, 3859 patients with lung cancer were selected from Yunnan Cancer Hospital. Firstly, the factors are described. Secondly, the area is divided into Xuanwei and Fuyuan XF) and non-Xuanwei and Fuyuan XF), and non-Xuanwei and non-XFFG. The factors of two different regions are compared and analyzed. The factors of survival were analyzed. [result] 1. Descriptive analysis showed that the overall mean age of onset was 57.32 鹵10.86 years old. There were 2692 males (69.8%) and 1167 females (30.2); there were 788 cases with XF (20. 4); 2195 cases with right lung and 1634 cases with left lung; 1888 cases with smoking; 285 cases with 7. 444; 1737 cases with adenocarcinoma and 45 cases with squamous cell carcinoma. The clinical manifestations were cough 72.8, expectoration 58.9%, blood in phlegm 27.3%, and the proportion of 鈪，

本文編號(hào)：1851416