發(fā)布時間：2018-05-02 13:07

  本文選題：胃腫瘤 + XRCC　； 參考：《現(xiàn)代腫瘤醫(yī)學》2017年05期

【摘要】：目的:綜合評價X線修復交叉互補基因3(X-ray repair cross-complementing group 3,XRCC3)Thr241Met單核苷酸基因多態(tài)性與胃癌易感性的關系。方法:計算機檢索相關期刊論文(CNKI)、中國生物醫(yī)學文獻數(shù)據(jù)庫(CBM)、中文科技期刊全文數(shù)據(jù)庫(VIP)、萬方數(shù)據(jù)庫、Pub Med、Cochrane Library,收集國內(nèi)外公開發(fā)表的關于XRCC3 Thr241Met基因多態(tài)性與胃癌易感性的病例-對照研究相關文獻。采用Stata12.0軟件進行統(tǒng)計學分析,計算合并比值比(odd ratio,OR)及95%可信區(qū)間(confidence interval,CI)。結(jié)果:共納入12篇文獻,從總的效應量分析,XRCC3 Thr241Met基因多態(tài)性與胃癌易感性間無明顯相關性,按種族進行亞組分析,提示在亞洲人群中隱性模型(MM vs MT+TT:OR=2.59,95%CI:1.98~3.39,P0.001)、等位模型(M vs T:OR=1.57,95%CI:1.05~2.35,P=0.028)、純合子模型(MM vs TT:OR=3.39,95%CI:2.17~5.31,P0.001)均具有統(tǒng)計學意義�；趯φ战M來源及是否符合Hardy-Weinberg遺傳平衡進行的亞組分析結(jié)果提示突變型與野生型無明顯統(tǒng)計學意義。結(jié)論:在亞洲人群中,XRCC3 Thr241Met基因多態(tài)性可能與胃癌易感性有關。
[Abstract]:Objective: to evaluate the association of single nucleotide polymorphisms of 3(X-ray repair cross-complementing group 3rCC3hthr241Met gene with susceptibility to gastric cancer. Methods: to search the full text database of Chinese periodicals (CNKI), Chinese Biomedical Literature Database (CBM), Chinese Sci-tech Journal Full-text Database (XRCC3 Thr241Met), Pub MedCochrane Library, and collect the published data on the polymorphism of XRCC3 Thr241Met gene at home and abroad. Case-control study of gastric cancer susceptibility. Statistical analysis was carried out with Stata12.0 software. The combined ratio was calculated as odd ratioor) and 95% confidence intervalescence. Results: there was no significant correlation between the polymorphism of XRCC3 Thr241Met gene and the susceptibility of gastric cancer. It is suggested that in Asian population, the hidden model (MM vs MT TTW OR2.5995) has statistical significance, and the allelic model (M vs TW OR 1.5795) has statistical significance, and the homozygous model (MM vs TTW OR3.3995 CI2.175.31 / P0.001) has statistical significance. The results of subgroup analysis based on the origin of control group and the genetic balance of Hardy-Weinberg showed that there was no significant difference between the mutant and the wild type. Conclusion: the polymorphism of XRCC3 Thr241Met gene may be associated with gastric cancer susceptibility in Asian population.
【作者單位】： 蘭州大學第一醫(yī)院腫瘤外科;
【基金】：甘肅省科技支撐計劃項目(編號:1504FKCA084) 甘肅省衛(wèi)生行業(yè)科研計劃項目(編號:GSWST2013-16)
【分類號】：R735.2

【參考文獻】

相關期刊論文 前4條

1 溫爽;劉天卿;劉飛飛;劉志敏;呂申;;胃癌發(fā)生過程中DNA修復蛋白表達的意義[J];大連醫(yī)科大學學報;2010年06期

2 Gerardo Rosati;Domenica Ferrara;Luigi Manzione;;New perspectives in the treatment of advanced or metastatic gastric cancer[J];World Journal of Gastroenterology;2009年22期

3 黃貴培;鄭宗立;蔡琳;;DNA損傷修復基因XRCC3 Thr241Met多態(tài)與賁門癌、非賁門部胃癌易感性關系的病例對照研究[J];中華流行病學雜志;2006年05期

4 Márcia Cristina Duarte;Jucimara Colombo;Andrea Regina Baptista Rossit;Alaor Caetano; Aldenis Albaneze Borim;Durval Wornrath;Ana Elizabete Silva;;Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer[J];World Journal of Gastroenterology;2005年42期

【共引文獻】

相關期刊論文 前10條

1 卓秋琪;樸洪宇;;運用Minitab軟件優(yōu)化S-1復方膠囊的研究[J];中國處方藥;2017年03期

2 張寶營;崔靜;姜雷;關泉林;;XRCC3 Thr241Met基因多態(tài)性與胃癌易感性的Meta分析[J];現(xiàn)代腫瘤醫(yī)學;2017年05期

3 蕭翊;劉小芳;杜濤;王凌云;馬z，

本文編號：1834033