本文關鍵詞：腫瘤靶向遞藥新策略的研究進展，由筆耕文化傳播整理發(fā)布。

腫瘤靶向遞藥新策略的研究進展

The development of novel tumor targeting delivery strategy

[1] [2]

GAO Hui-le,JIANG Xin-guo（1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610

[1]四川大學華西藥學院、靶向藥物與釋藥系統(tǒng)教育部重點實驗室,四川成都610041; [2]復旦大學藥學院、教育部智能化遞藥重點實驗室,上海201203

文章摘要：腫瘤已成為危害人類健康和生命的第二大疾病。盡管已有多種抗腫瘤藥物上市,但是由于腫瘤靶向性不佳,腫瘤內蓄積能力較差,使得抗腫瘤效果不盡如人意。如何高效地將抗腫瘤藥物遞送入腫瘤,提高藥物在腫瘤部位的濃度,降低其在正常組織中的濃度,成為制藥領域研究的熱點。為達到此目的,研究者設計了多種納米靶向遞藥系統(tǒng),并取得了一定的效果。本文將對目前已有的腫瘤靶向遞藥策略進行綜述,對其中存在的問題進行討論。

Abstr：Tumor is one of the most serious threats for human being. Although many anti-tumor drugs are approved for clinical use, the treatment outcome is still modest because of the poor tumor targeting efficiency and low accumulation in tumor. Therefore, it is important to deliver anti-tumor drug into tumor efficiently, elevate drug concentration in tumor tissues and reduce the drug distribution in normal tissues. And it has been one of the most attractive directions of pharmaceutical academy and industry. Many kinds of strategies, especially various nanoparticulated drug delivery systems, have been developed to address the critical points of complex tumor microenvironment, which are partially or mostly satisfied for tumor treatment. In this paper, we carefully reviewed the novel targeting delivery strategies developed in recent years. The most powerful method is passive targeting delivery based on the enhanced permeability and retention（EPR） effect, and most commercial nanomedicines are based on the EPR effect. However, the high permeability and retention require different particle sizes, thus several kinds of size-changeable nanoparticles are developed, such as size reducible particles and assemble particles, to satisfy the controversial requirement for particle size and enhance both tumor retention and penetration. Surface charge reversible nanoparticles also shows a high efficiency because the anionic charge in blood circulation and normal organs decrease the unintended internalization. The charge can change into positive in tumor microenvironment, facilitating drug uptake by tumor cells. Additionally, tumor microenvironment responsive drug release is important to decrease drug side effect, and many strategies are developed, su

文章關鍵詞：

Keyword：:neoplasm tumor microenvironment drug delivery system

課題項目：國家自然科學基金資助項目（31571016;81402866）

作者信息：會員可見

  本文關鍵詞：腫瘤靶向遞藥新策略的研究進展，，由筆耕文化傳播整理發(fā)布。