本文選題：隱睪 + 睪丸癌　； 參考：《新疆醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的：系統(tǒng)評(píng)價(jià)單側(cè)隱睪與對(duì)側(cè)睪丸癌的相關(guān)性,為臨床研究及實(shí)踐提供參考。方法：計(jì)算機(jī)檢索PubMed、EMbase、WanFang Data、CNKI、Cochrane和CBM數(shù)據(jù)庫(kù),檢索年限為1980年至今,收集所有單側(cè)隱睪與對(duì)側(cè)睪丸癌相關(guān)性的隊(duì)列研究及病歷對(duì)照研究的文獻(xiàn)。要求符合隱睪及睪丸癌相關(guān)性研究,并能提供具體數(shù)據(jù)的文獻(xiàn)。由3名質(zhì)量控制員按照設(shè)定的納入標(biāo)準(zhǔn)和排除標(biāo)準(zhǔn)檢測(cè)相關(guān)的參考文獻(xiàn),進(jìn)行質(zhì)量評(píng)價(jià)和資料提取。應(yīng)用RevMan5.2版軟件進(jìn)行數(shù)據(jù)的Meta分析處理；本系統(tǒng)評(píng)價(jià)療效資料均為分類變量,故以相對(duì)危險(xiǎn)度或比值比(RR或OR)及其95%可信區(qū)間(95%CI)來(lái)表示變量。結(jié)果：共檢索出文獻(xiàn)1630篇,符合要求12篇,排除7篇,其中符合要求的5篇納入此meta分析。結(jié)果共涉及5個(gè)病例對(duì)照研究,男性隱睪癥138例,86(62%)在同側(cè)和52(38%)在對(duì)側(cè)。合并的相對(duì)危險(xiǎn)度在同側(cè)和對(duì)側(cè)睪丸癌中分別為：[OR=3.04,95% CI(1.88,4.91),P=0.15]和[OR=1.98,95% CI (1.12,3.50), P=0.09]。結(jié)論：?jiǎn)蝹?cè)隱睪導(dǎo)致睪丸癌的風(fēng)險(xiǎn)在雙側(cè)睪丸均會(huì)增加,但同側(cè)風(fēng)險(xiǎn)會(huì)高于對(duì)側(cè)。因?yàn)槭芗{入研究數(shù)量和質(zhì)量的限制,上述結(jié)論尚有賴于進(jìn)一步開展更多大樣本、多中心、高質(zhì)量的隊(duì)列研究加以驗(yàn)證。
[Abstract]:Objective: to evaluate the correlation between unilateral cryptorchidism and contralateral testicular carcinoma and to provide reference for clinical study and practice. Methods: a computer-based search was carried out on PubMedus EMbase Fang data (CNKI) Cochrane and CBM databases for the period from 1980 to present. All the cohort studies on the correlation between unilateral cryptorchidism and contralateral testicular carcinoma and the comparative study of medical records were collected. It is required to be consistent with the study of the association of cryptorchidism and testicular carcinoma, and to provide specific data in the literature. The quality evaluation and data extraction were carried out by three quality controllers according to the relevant reference documents of inclusion standard and exclusion standard test. The RevMan5.2 software was used to analyze and process the data. The data of the system were classified variables, so the relative risk or ratio of RR or ORs and 95% confidence interval (95% CI) were used to represent the variables. Results: a total of 1630 articles were retrieved, 12 were in accordance with the requirements, 7 were excluded, 5 of which were included in the meta analysis. Results A total of 5 case-control studies were conducted. 138 cases of male cryptorchidism were located on the ipsilateral side and 52 on the contralateral side. The relative risk of concomitant testicular carcinoma in ipsilateral and contralateral testicular carcinoma was: [ORO 3.04% 95% CI 1.88 鹵4.91 P0. 15] and [ORL 1.98 95% CI 1.12 + 3.50, P0. 09]. Conclusion: the risk of testicular carcinoma caused by unilateral cryptorchidism is increased in both testes, but the ipsilateral risk is higher than that of contralateral testicular carcinoma. Because of the limitation of the quantity and quality of the study, the above conclusions depend on further large sample, multi-center, high-quality cohort study to verify.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R737.21
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本文編號(hào)：1805408