本文選題：賁門癌 + 根治性全胃切除術　； 參考：《蘭州大學》2017年碩士論文

【摘要】：目的系統(tǒng)評價根治性全胃切除術及根治性近端胃切除術治療賁門癌的療效及并發(fā)癥。方法計算機檢索PubMed、Web of Science、The Cochrane Library、中國生物醫(yī)學文獻數據庫、萬方數據庫和中國知網等數據庫,查找關于根治性全胃切除術及根治性近端胃切除術治療賁門癌的相關研究文獻,檢索時限均從建庫至2016年10月18日。由2位評價員按納入與排除標準獨立篩選文獻、提取資料并評價質量后,采用RevMan 5.3軟件進行Meta分析。結果共納入8個研究,522例患者。Meta分析結果顯示:與根治性近端胃切除術相比,根治性全胃切除術治療賁門癌在5年生存率[OR=1.84,95%CI(1.16,2.92),P=0.01]、3年生存率[OR=1.95,95%CI(1.30,2.93),P=0.001]、吻合口瘺發(fā)生率[OR=0.39,95%CI(0.16,0.94),P=0.03]、反流發(fā)生率[OR=0.12,95%CI(0.04,0.36),P=0.0002]方面差異均有統(tǒng)計學意義。在1年生存率[OR=1.31,95%CI(0.66,2.60),P=0.44]、吻合口狹窄發(fā)生率[OR=0.53,95%CI(0.16,1.69),P=0.28]、腸梗阻發(fā)生率[OR=0.39,95%CI(0.14,1.09),P=0.07]、切口感染發(fā)生率[OR=0.79,95%CI(0.19,3.33),P=0.75]方面差異無統(tǒng)計學意義。結論現(xiàn)有證據表明,全胃切除術治療賁門癌效果良好且并發(fā)癥少。鑒于納入研量有限,上述結論尚需開展更多研究予以驗證。
[Abstract]:Objective to evaluate the efficacy and complications of radical total gastrectomy and radical proximal gastrectomy in the treatment of cardiac carcinoma. Methods We searched the online database of PubMedus Web of Science of the Cochrane Library, the Chinese Biomedical Literature Database, the Wanfang Database and the Chinese knowledge Network, and searched for the relevant literatures on radical total gastrectomy and radical proximal gastrectomy in the treatment of cardiac carcinoma. The time limit for retrieval is from the construction of the database to October 18, 2016. According to the inclusion and exclusion criteria, two evaluators independently sifted the literature, extracted the data and evaluated the quality, and then analyzed the data by RevMan 5.3 software. Results A total of 522 patients were included in 8 studies. Meta-analysis showed that compared with radical proximal gastrectomy, The 5-year survival rate of radical total gastrectomy for cardiac cancer [OR1.8495 CIQ 1.162.92], the 3-year survival rate (OR1.9595CII 1.302.93P0.001), the incidence of anastomotic fistula (OR0.3995CI0.160.94P0.03), the incidence of reflux [OR0.1295CI0.040.36Pn002] were statistically significant. There was no significant difference in the incidence of anastomotic stenosis (OR0.53 / 95), intestinal obstruction (OR0.39 / 95CII 0.141.09P0.07), incisional infection (OR0.799CII 0.193.33P0.75) at 1 year survival rate [OR1. 31C 95 CIQ], anastomotic stoma stenosis rate (OR0. 5395 CII = 0. 669 P0. 28), and incisional infection rate (OR0.79 / 95CIT = 0. 193.33P0. 75), and there was no significant difference in the incidence of intestinal obstruction (OR 0.39 / 95 CII = 0.141.09 P0.07), and there was no significant difference in the incidence of incisional infection [OR0.79 / 95CIT 0.193.33P0.75] Conclusion the available evidence shows that total gastrectomy is effective in treating cardiac carcinoma with less complications. In view of the limited number of studies included, more studies are needed to verify the above conclusions.
【學位授予單位】：蘭州大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R735.2

【參考文獻】

相關期刊論文 前10條

1 汪文杰;任景麗;吳會芳;胡桂明;解澎;常佳;王玉香;;賁門癌手術不同路徑療效的Meta分析[J];東南大學學報(醫(yī)學版);2016年06期

2 呂會來;張麗;溫士旺;李勇;張月峰;田子強;;術前新輔助化療對局部進展期賁門癌治療效果的影響研究[J];現(xiàn)代中西醫(yī)結合雜志;2016年30期

3 Weihan Zhang;Xinzu Chen;Kai Liu;Kun Yang;Xiaolong Chen;Ying Zhao;Yongfan Zhao;Jiaping Chen;Longqi Chen;Jiankun Hu;;Comparison of survival outcomes between transthoracic and transabdominal surgical approaches in patients with Siewert-Ⅱ/Ⅲ esophagogastric junction adenocarcinoma: a single-institution retrospective cohort study[J];Chinese Journal of Cancer Research;2016年04期

4 王銳;;食管胃結合部腺癌患者經胸與經腹食管裂孔手術的療效比較[J];實用癌癥雜志;2016年05期

5 夏萬泓;劉大江;駱偉;;128層螺旋CT診斷腹部段食管癌與賁門癌淋巴結轉移臨床價值研究[J];陜西醫(yī)學雜志;2016年03期

6 石會勇;甄亞男;王斌;霍守俊;徐忠法;;近端胃切除術與全胃切除術治療賁門癌的臨床療效對比[J];中國衛(wèi)生標準管理;2016年04期

7 蔡杰;彭俊;王文憑;Y胂，

本文編號：1804925