本文選題：乳腺腫瘤 + 分子分型�。� 參考：《中華腫瘤防治雜志》2017年05期

【摘要】：目的 Notch信號(hào)通路在乳腺癌中存在異常表達(dá),但在不同分子分型乳腺癌中的表達(dá)情況鮮見報(bào)道。本研究將探討不同分子分型乳腺浸潤(rùn)性導(dǎo)管癌組織中Notch1和JAG1蛋白表達(dá)及其與臨床病理特征之間的關(guān)系。方法收集濱州醫(yī)學(xué)院附屬醫(yī)院病理科2012-01-06-2014-12-30存檔的乳腺浸潤(rùn)性導(dǎo)管癌病例240例,根據(jù)ER、PR、HER2、Ki-67免疫組化結(jié)果分為管腔A型、管腔B型、HER2過表達(dá)型及三陰性型4組,每組60例,采用免疫組化En-Vision法檢測(cè)不同分子分型乳腺癌中Notch1、JAG1蛋白的表達(dá)情況,對(duì)各分型乳腺癌組織的陽性表達(dá)率進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果各分型乳腺癌組織中Notch1的陽性表達(dá)差異有統(tǒng)計(jì)學(xué)意義(P=0.010,P0.05),其中三陰性乳腺癌(86.67%)與管腔A型(56.67%)比較(P0.001),HER2過表達(dá)型(83.33%)與管腔A型(56.67%)比較,差異均有統(tǒng)計(jì)學(xué)意義,P0.001;Notch1的陽性表達(dá)與淋巴結(jié)轉(zhuǎn)移相關(guān)(P=0.017,P0.05),與臨床分期(P=0.005,P0.01)、組織學(xué)分級(jí)(P=0.009,P0.01)顯著相關(guān),與ER表達(dá)(r_s=-0.206,P=0.001,P0.01)、PR表達(dá)(r_s=-0.187,P=0.005,P0.01)顯著負(fù)相關(guān),而與患者年齡、腫塊大小無關(guān)。各分型乳腺癌組織中JAG1的陽性表達(dá)差異有統(tǒng)計(jì)學(xué)意義(P=0.035,P0.05),以三陰性乳腺癌陽性表達(dá)率最高,但各組間兩兩比較差異無統(tǒng)計(jì)學(xué)意義;JAG1陽性表達(dá)與ER表達(dá)(r_s=-0.142,P=0.015,P0.05)、PR表達(dá)(r_s=-0.127,P=0.035,P0.05)呈負(fù)相關(guān);Notch1和JAG1之間無明顯相關(guān)性。結(jié)論 Notch1陽性表達(dá)與ER、PR表達(dá)顯著負(fù)相關(guān),與乳腺癌的組織學(xué)分級(jí)、淋巴結(jié)轉(zhuǎn)移及臨床分期密切相關(guān),并在HER2過表達(dá)型,尤其是三陰性乳腺癌組織中存在高表達(dá),有可能成為三陰性乳腺癌新的治療靶點(diǎn)。
[Abstract]:Objective there is abnormal expression of Notch signaling pathway in breast cancer, but it is rarely reported in different molecular types of breast cancer.The purpose of this study was to investigate the expression of Notch1 and JAG1 in breast invasive ductal carcinoma with different molecular types and their relationship with clinicopathological features.Methods 240 cases of invasive ductal carcinoma of breast were collected from Department of Pathology, affiliated Hospital of Binzhou Medical College, from January to June 2014-12-30. According to the immunohistochemical results of ERB HER2 Ki-67, 240 cases were divided into 4 groups: type A, type B, and type B, with 60 cases in each group.Immunohistochemical En-Vision method was used to detect the expression of Notch1 and JAG1 protein in different molecular types of breast cancer, and the positive expression rate of Notch1 and JAG1 protein was analyzed statistically.Results there were significant differences in the positive expression of Notch1 between the three negative breast cancer tissues (P 0.010 and P 0.05, including three negative breast cancer (86.67)) and the lumen A (56.67) (P 0.001 HER2 overexpression type (83.33) and the lumen A (56.67)).There was significant correlation between the positive expression of P0.001ntch1 and lymph node metastasis (P0. 017 / P0. 05), clinical stage P0. 005 / P0. 01, histological grade P0. 009 / P0. 01), and the positive expression of P0. 001- 0. 206P0. 001p0. 01PR was negatively correlated with the age of the patients and the size of the tumor, but it was not correlated with the age of the patients and the size of the tumor. The positive expression of P0. 001ntch1 was significantly correlated with the expression of P0. 017 and P0. 005P0. 01, but not correlated with the age of the patients and the size of the tumor.The positive expression of JAG1 in breast cancer was significantly different among the three types of breast cancer, and the positive expression rate of JAG1 was the highest in triple-negative breast cancer.But there was no significant difference between the two groups. There was no significant correlation between the positive expression of JAG1 and the expression of ER, rstch1 and JAG1. There was no significant correlation between the positive expression of JAG1 and the expression of rsser-0.127 P0. 035 and JAG1.Conclusion the positive expression of Notch1 is negatively correlated with the expression of ERP PR, and is closely related to the histological grade, lymph node metastasis and clinical stage of breast cancer, and is highly expressed in the overexpression of HER2, especially in triple-negative breast cancer.It is possible to become a new therapeutic target for triple negative breast cancer.
【作者單位】： 濱州醫(yī)學(xué)院附屬醫(yī)院病理科;濱州醫(yī)學(xué)院病理學(xué)教研室;
【基金】：山東省自然科學(xué)基金(ZR2010HM096)
【分類號(hào)】：R737.9

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