本文選題：肺腺癌 + Gab2��； 參考：《廣西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:探索在肺腺癌中Gab2高表達(dá)與臨床病理特征之間的關(guān)系,探索Gab2高表達(dá)與臨床預(yù)后之間的關(guān)系,旨在探索新的臨床預(yù)后判斷指標(biāo),探索新的靶向治療靶點(diǎn)。方法:取2012年7月3日至2015年2015年1月9日于手術(shù)切除的病理標(biāo)本,肺腺癌組織、癌旁組織病理蠟塊,采用免疫組織化學(xué)SP法檢測(cè)檢Gab2蛋白的表達(dá),分析其高表達(dá)臨床病理的關(guān)系并作出預(yù)后分析。結(jié)果:肺腺癌中Gab2的表達(dá)情況,癌組織與癌旁高表達(dá)卡方檢驗(yàn)P值=0.000。肺腺癌中Gab2高表達(dá)與TMN分期、脈管癌栓卡方檢驗(yàn)P值=0.045、P值=0.011。生存率的單因素Log-rank檢驗(yàn),Gab2高、低表達(dá)P值=0.040,脈管癌栓陽(yáng)、陰性P值=0.001。結(jié)論:Gab2在肺腺癌組織中的高表達(dá)率為53.3%,高于其在癌旁組織中高表達(dá)率6.67%,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。在肺腺癌組織中Gab2蛋白的高表達(dá)與患者的性別、年齡、分化程度及淋巴結(jié)轉(zhuǎn)移無(wú)關(guān)(P0.05),而與TMN分期、脈管癌栓陽(yáng)性有關(guān)(P0.05)。在肺腺癌患者中,淋巴結(jié)轉(zhuǎn)移、TNM分期、Gab2高表達(dá)以及脈管癌栓陽(yáng)性,這些因素都是影響肺腺癌患者預(yù)后的重要因素(P0.05)。
[Abstract]:Objective: to explore the relationship between the high expression of Gab2 and the clinicopathological features in lung adenocarcinoma and the relationship between the high expression of Gab2 and the clinical prognosis.Methods: from July 3, 2012 to January 9, 2015, the expression of Gab2 protein was detected by immunohistochemical SP method in lung adenocarcinoma and paracancerous tissues, which were surgically resected from July 3, 2012 to January 9, 2015.The relationship between high expression and clinicopathology was analyzed and the prognosis was analyzed.Results: the expression of Gab2 in lung adenocarcinoma, the high expression of chi-square test (P = 0.000).The high expression of Gab2 and TMN stage were detected in lung adenocarcinoma.In univariate Log-rank test of survival rate, Gab2 was high, low expression P value was 0.040, vessel tumor thrombus positive, negative P value was 0.001.Conclusion the high expression rate of w Gab2 in lung adenocarcinoma is 53.3%, which is higher than that in paracancerous tissues (6.67%). The difference is statistically significant (P 0.05).The high expression of Gab2 protein in lung adenocarcinoma was not related to sex, age, differentiation and lymph node metastasis, but was related to TMN stage and positive vascular tumor thrombus.In patients with lung adenocarcinoma, the high expression of Gab2 in lymph node metastasis and the positive expression of vascular tumor thrombus were all important factors affecting the prognosis of lung adenocarcinoma patients (P 0.05).
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R734.2

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本文編號(hào)：1742732