本文選題：蛋白酶激活受體　切入點：骨癌疼痛　出處：《山東醫(yī)藥》2017年47期 　論文類型：期刊論文

【摘要】：蛋白酶激活受體2(PAR2)是G蛋白偶聯(lián)受體家族成員,由細胞內(nèi)袢與C-末端、7個跨膜螺旋結(jié)構(gòu)、N-末端與細胞外袢組成,廣泛分布于各個組織系統(tǒng),包括表皮、心血管、免疫系統(tǒng)、外周與中樞神經(jīng)系統(tǒng)等,通過跨膜信號轉(zhuǎn)導調(diào)節(jié)細胞的各種功能。骨癌疼痛大多數(shù)是由癌癥轉(zhuǎn)移到骨引起,常常伴隨骨相關(guān)事件發(fā)生,嚴重影響患者生存質(zhì)量。活化的PAR2通過調(diào)節(jié)相關(guān)的特殊信號通路,如P物質(zhì)、降鈣素基因相關(guān)肽、腦源性神經(jīng)營養(yǎng)因子、瞬時感受器電位通道、絲裂原激活的蛋白激酶/細胞外信號調(diào)節(jié)激酶、N-甲基-D-天門冬氨酸受體、蛋白激酶A、蛋白激酶C、酟阿片受體等,參與骨癌疼痛痛覺敏化及痛覺信息的傳遞和調(diào)控。
[Abstract]:Protease activated receptor 2 (PAR2) is a member of the G protein-coupled receptor family. It is composed of intracellular loop and C-terminal, seven transmembrane helical structure N- terminal and extracellular loop. It is widely distributed in various tissue systems, including epidermis, cardiovascular and immune system. Peripheral and central nervous systems regulate cell functions through transmembrane signal transduction. Pain in bone cancer is mostly caused by the metastasis of cancer to the bone, often accompanied by bone related events. Activated PAR2 regulates specific signaling pathways, such as substance P, calcitonin gene-related peptide, brain-derived neurotrophic factor, transient receptor potential channel, and so on. Mitogen-activated protein kinase / extracellular signal-regulated kinase N-methyl-Daspartate receptor, protein kinase A, protein kinase C, opioid receptor participate in pain sensitization and the transmission and regulation of pain information in bone cancer.
【作者單位】： 三峽大學醫(yī)學院;
【基金】：國家自然科學基金資助項目(81503381)
【分類號】：R738

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