本文選題：急性淋巴細(xì)胞白血病　切入點(diǎn)：谷胱甘肽S-轉(zhuǎn)移酶　出處：《中國(guó)實(shí)驗(yàn)血液學(xué)雜志》2017年01期 　論文類(lèi)型：期刊論文

【摘要】：目的:深入分析GST基因缺失與兒童ALL遺傳易感性的關(guān)系。方法:基于納入和排除標(biāo)準(zhǔn)計(jì)算機(jī)檢索PubMed、Embase、相關(guān)期刊論文(CNKI)和萬(wàn)方數(shù)據(jù)庫(kù)。檢索時(shí)間截止至2015年8月,檢索過(guò)程中無(wú)語(yǔ)言限制。采用STATA 12.0軟件計(jì)算OR及其95%CI,敏感性分析驗(yàn)證結(jié)論的穩(wěn)健性,漏斗圖檢測(cè)發(fā)表偏倚。結(jié)果:本研究共納入27項(xiàng)病例和對(duì)照研究,包括3736例患者和5549例對(duì)照。Meta分析結(jié)果顯示,GSTM1和GSTT1缺失基因型與兒童ALL之間的總OR值分別為1.41(95%CI:1.21~1.65)和1.26(95%CI:1.05~1.50),均較對(duì)照組顯著降低,差異具有統(tǒng)計(jì)學(xué)意義(P=0.000,P=0.012)。在亞組分析中,黑種人群、亞洲人群、PB組(來(lái)自普通人的對(duì)照)、HB組(來(lái)自醫(yī)院的對(duì)照)、"≥100病例數(shù)"組和"100病例數(shù)"組攜帶GSTM1基因突變的兒童發(fā)生ALL的風(fēng)險(xiǎn)顯著增高。而對(duì)于GSTT1,其多態(tài)性?xún)H與亞洲人群、PB組和"≥100病例數(shù)"組的發(fā)病風(fēng)險(xiǎn)有相關(guān)性。結(jié)論:GSTM1和GSTT1缺失基因型可能是兒童ALL的易感因素,但該結(jié)論有待進(jìn)一步證實(shí)。
[Abstract]:Objective: to analyze the relationship between GST gene deletion and genetic susceptibility to ALL in children. Methods: PubMedMed Embase, CNKI and Wanfang databases were searched based on inclusion and exclusion standard computer. The search time was up to August 2015. STATA 12.0 software was used to calculate OR and its 95CI.The sensitivity analysis was used to verify the robustness of the conclusions, and funnel graph was used to detect publication bias. Results: 27 case and control studies were included in this study. Meta-analysis of 3736 patients and 5549 controls showed that the total OR values between GSTM1 and GSTT1 deletion genotypes and ALL in children were 1.41-95 CI: 1.211.65) and 1.2695 CI: 1.05C 1.50, respectively, which were significantly lower than those in the control group (P 0.000, P 0.012). The risk of developing ALL in children with GSTM1 gene mutation was significantly increased in Asian population (normal control group (control group from hospital, "鈮，

本文編號(hào)：1613283