本文選題：癌　切入點(diǎn)：肝細(xì)胞　出處：《中國(guó)普通外科雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的:探討合并肌少癥肝細(xì)胞癌患者的臨床病理特征及術(shù)后預(yù)后。方法:回顧性分析2010年3月—2016年6月期間就診于武漢大學(xué)人民醫(yī)院因肝細(xì)胞癌行肝切除術(shù)的139例患者的臨床病理及隨訪資料。結(jié)果:139例患者中,56例(40.3%)合并肌少癥。與非肌少癥患者比較,肌少癥患者體質(zhì)量指數(shù)與骨骼肌指數(shù)明顯降低、高TNM分期與微血管浸潤(rùn)比例明顯增加(均P0.05);術(shù)后發(fā)生感染(14.3%vs.3.6%)、嚴(yán)重并發(fā)癥(Clavien-Dindo Ⅲ級(jí)及以上)(19.6%vs.6.0%)、總并發(fā)癥(35.7 vs.13.3%)的發(fā)生率明顯升高(均P0.05);術(shù)后恢復(fù)時(shí)間(17.35 d vs.11.33 d)明顯延長(zhǎng),需要入ICU治療的患者比例(12.5%vs.2.4%)明顯增加(均P0.05);術(shù)后總生存時(shí)間明顯減少(P0.05)。Cox比例風(fēng)險(xiǎn)模型結(jié)果顯示,合并肌少癥是影響肝細(xì)胞癌患者術(shù)后生存的獨(dú)立危險(xiǎn)因素(P=0.001,HR=2.090,95%CI=1.340~3.259)。結(jié)論:合并肌少癥的肝細(xì)胞癌患者術(shù)后并發(fā)癥發(fā)率增加、恢復(fù)慢,且術(shù)后預(yù)后不良。
[Abstract]:Objective: to investigate the clinicopathological features and postoperative prognosis of hepatocellular carcinoma complicated with hypomyosis. Methods: a retrospective analysis of the patients undergoing hepatectomy for hepatocellular carcinoma in Renmin Hospital of Wuhan University from March 2010 to June 2016 was conducted. Results of 139 cases, 56 cases (40.3%) were complicated with hypothyroidism. Body mass index (BMI) and skeletal muscle index (BMI) were significantly decreased in oligocytopathic patients. The incidence of high TNM stage and microvascular infiltration was significantly increased (all P0.05; the incidence of postoperative infection was 14.3vs.3.6m; severe complications were Clavien-Dindo 鈪，

本文編號(hào)：1613132