本文選題：前列腺癌　切入點(diǎn)：骨轉(zhuǎn)移　出處：《中華男科學(xué)雜志》2017年03期 　論文類(lèi)型：期刊論文

【摘要】：目的:本研究觀察低血清睪酮水平是否能獨(dú)立預(yù)測(cè)前列腺癌骨轉(zhuǎn)移的風(fēng)險(xiǎn)。方法:本研究納入標(biāo)準(zhǔn)為接受前列腺穿刺證實(shí)為前列腺癌,并進(jìn)行骨掃描檢測(cè)的患者165例,患者年齡58~78(66.6±5.3)歲。所有患者在診斷為前列腺癌之前未接受過(guò)雄激素剝奪治療、化療、放射治療。我們收集患者的臨床資料包括:年齡、前列腺穿刺Gleason評(píng)分、血清性激素、前列腺特異抗原(PSA)和堿性磷酸酶(ALP)水平,其中血清標(biāo)本在前列腺穿刺之前的清晨收集。根據(jù)骨掃描結(jié)果,將前列腺癌分為骨掃描組和非骨掃描組,通過(guò)單因素分析篩選出有差異的因子,并進(jìn)行了多因素非條件回歸模型篩選出獨(dú)立預(yù)測(cè)因子。結(jié)果:165例前列腺癌患者納入本次研究,依據(jù)骨掃描結(jié)果分為前列腺癌骨轉(zhuǎn)移組和非骨轉(zhuǎn)移組。單因素分析結(jié)果顯示年齡(P=0.126)、黃體生成素(P=0.930)、卵泡刺激素(P=0.763)和雌二醇(P=0.256)在兩組之間并沒(méi)有統(tǒng)計(jì)學(xué)差異,而血清PSA(P0.001)、前列腺穿刺的Gleason評(píng)分(P0.001)、血清睪酮(P=0.013)及血清堿性磷酸酶(P0.001)在預(yù)測(cè)骨轉(zhuǎn)移有統(tǒng)計(jì)學(xué)意義。多因素分析結(jié)果顯示低血清睪酮(P=0.531)、前列腺穿刺Gleason評(píng)分(P=0.898)并不能作為獨(dú)立因子預(yù)測(cè)前列腺癌骨轉(zhuǎn)移的風(fēng)險(xiǎn),而血清堿性磷酸酶(P0.001,OR=1.018[1.011~1.026])和血清PSA(P0.001,OR=1.029[1.015~1.044])是有效的預(yù)測(cè)前列腺癌骨轉(zhuǎn)移的風(fēng)險(xiǎn)因子。結(jié)論:低血清睪酮水平與前列腺癌骨轉(zhuǎn)移密切相關(guān),但不能成為有效的預(yù)測(cè)前列腺癌骨轉(zhuǎn)移的風(fēng)險(xiǎn)因子。
[Abstract]:Objective: to investigate whether low serum testosterone levels can independently predict the risk of bone metastasis in prostate cancer. Methods: 165 patients with prostate cancer confirmed by prostate puncture and examined by bone scan were included in this study. All patients were not treated with androgen deprivation, chemotherapy, radiotherapy before diagnosis of prostate cancer. Our clinical data included age, prostate puncture Gleason score, serum sex hormone. Serum samples were collected early in the morning before prostate puncture. According to the results of bone scan, prostate cancer was divided into bone scanning group and non bone scanning group. Independent predictors were screened by univariate analysis and multivariate non-conditional regression model. Results: 165 prostate cancer patients were included in this study. Univariate analysis showed that there was no significant difference between the two groups in age (P < 0. 126), luteinizing hormone (P) 0. 930, follicle stimulating hormone (P) 0. 763) and estradiol (P) 0. 256). However, serum PSA-P0.001, Gleason score of prostate puncture P0.001, serum testosterone P0.013) and serum alkaline phosphatase P0.001) had statistical significance in predicting bone metastasis. Multivariate analysis showed that low serum testosterone P0. 531, prostate puncture Gleason score P0. 898) could not be used as a predictor of bone metastasis. Independent factors predict the risk of bone metastasis in prostate cancer. Serum alkaline phosphatase (P0.001) and serum PSAP 0.001 OR1.029 [1.0151.044] are effective risk factors for predicting bone metastasis of prostate cancer. Conclusion: low serum testosterone level is closely associated with bone metastasis of prostate cancer. However, it is not an effective risk factor for predicting bone metastasis in prostate cancer.
【作者單位】： 九江學(xué)院;九江學(xué)院附屬醫(yī)院東院泌尿外科;南昌大學(xué)第一附屬醫(yī)院泌尿外科;
【基金】：江西省衛(wèi)生和計(jì)劃生育委員會(huì)科技支撐課題(20157083,20157084) 九江市支撐科技計(jì)劃(20140024)~~
【分類(lèi)號(hào)】：R737.25

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