本文關(guān)鍵詞： 羥考酮 加巴噴丁 鎮(zhèn)痛藥 日均費(fèi)用 癌痛 生活質(zhì)量　出處：《中國新藥與臨床雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的觀察羥考酮聯(lián)合加巴噴丁用于癌痛患者的鎮(zhèn)痛效果及患者滿意度。方法選擇60例疼痛視覺模擬量表(VAS)評分7分以上的癌痛患者經(jīng)嗎啡滴定后隨機(jī)分為兩組,每組30例。對照組給予羥考酮的基礎(chǔ)上加服安慰劑,試驗組給予羥考酮的基礎(chǔ)上加服加巴噴丁。觀察比較患者服藥前后VAS評分,及服藥后1周和1、3、6個月羥考酮的日劑量、日止痛藥費(fèi)用、生活質(zhì)量評分。結(jié)果 1個月后,兩組患者羥考酮日均劑量差異無顯著意義(P0.05);3個月后,對照組羥考酮日均劑量顯著高于試驗組[(58.0±15.2)mg vs.(33.4±11.0)mg,P0.001];試驗組日均止痛藥費(fèi)用則明顯低于對照組[(34.5±10.2)元vs.(52.4±13.7)元,P0.01];兩組患者服藥后各時間點(diǎn)生活質(zhì)量評分均較治療前增加(P0.05);試驗組3個月后和6個月后生活質(zhì)量評分均高于對照組(分別為46.8±4.5 vs.43.5±4.6,P=0.007和46.5±4.8 vs.41.4±4.3,P0.001)。兩組患者嗜睡和頭暈的發(fā)生率相似(P0.05),而對照組惡心、嘔吐(P=0.038)和便秘(P0.001)的發(fā)生率顯著高于試驗組。結(jié)論重度癌痛患者采用羥考酮聯(lián)合加巴噴丁有利于控制疼痛,降低羥考酮的用量,減少止痛藥物費(fèi)用,并且有利于減少惡心、嘔吐和便秘的發(fā)生率,改善生活質(zhì)量。
[Abstract]:Objective to observe the analgesic effect and patient satisfaction of patients with cancer pain treated with hydroxycodone combined with batapentin. Methods 60 patients with cancer pain with visual analogue pain scale (VASS) score of 7 or more were randomly divided into two groups after morphine titration. There were 30 patients in each group. The control group was given hydroxycodone plus placebo, and the trial group was given hydroxycodone plus gabapentine. The VAS scores of patients before and after administration were observed and compared, and the daily dose of hydroxycodone 1 week and 1 3, 6 months after administration were observed and compared. Results after one month, there was no significant difference in the daily average dose of hydroxycodone between the two groups, and after 3 months, there was no significant difference between the two groups. The average daily dose of hydroxycodone in the control group was significantly higher than that in the test group [58.0 鹵15.2mg vs.(33.4 鹵11.0mg / g P0.001], and the average daily painkiller cost in the test group was significantly lower than that in the control group [34.5 鹵10.2 yuan vs.(52.4 鹵13.7 yuan P0.01]. After 3 months and 6 months, the scores of quality of life were higher than those of the control group (46.8 鹵4.5 vs.43.5 鹵4.6 vs.43.5, P 0.007 and 46.5 鹵4.8 vs.41.4 鹵4.3 vs.41.4 鹵4.3 vs.41.4 鹵4.3 vs.41.4 鹵0.001g, respectively). The incidence of drowsiness and dizziness in the two groups was similar to that in the control group (P 0.05), while in the control group, the incidence of drowsiness and dizziness was similar. The incidence of vomiting and constipation in patients with severe cancer pain was significantly higher than that in the trial group. Conclusion it is beneficial to control pain, reduce the dosage of hydroxycodone, reduce the cost of painkillers and reduce nausea in patients with severe cancer pain. The incidence of vomiting and constipation improves the quality of life.
【作者單位】： 紹興市人民醫(yī)院麻醉科;紹興市人民醫(yī)院醫(yī)學(xué)研究中心;紹興市人民醫(yī)院重癥醫(yī)學(xué)科;
【基金】：浙江省自然基金(LY15H030013) 浙江省衛(wèi)生廳項目(2016KYB197)
【分類號】：R730.5

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