本文關(guān)鍵詞： 胃腸道間質(zhì)腫瘤 纖維蛋白原 纖維蛋白纖維蛋白原降解物 預(yù)后　出處：《中國(guó)普通外科雜志》2017年04期 　論文類(lèi)型：期刊論文

【摘要】：目的:探討術(shù)前血漿D-二聚體(D-D)及纖維蛋白原含量(FIB)對(duì)胃腸道間質(zhì)瘤(GIST)患者術(shù)后預(yù)后的預(yù)測(cè)價(jià)值。方法:收集2010年1月—2015年12月手術(shù)治療的170例GIST患者臨床病理及隨訪(fǎng)資料,分析術(shù)前D-D及FIB水平與患者預(yù)后的關(guān)系。結(jié)果:170例GIST患者中男91例,女79例;多見(jiàn)于50~70歲年齡段;腫瘤原發(fā)部位最常見(jiàn)于胃(122例,71.8%),其次為小腸(34例,20.0%)。全組術(shù)后3、5年無(wú)復(fù)發(fā)生存率(RFS)分別為85%、75%。以生存結(jié)局(出現(xiàn)轉(zhuǎn)移或復(fù)發(fā))為狀態(tài)變量的ROC曲線(xiàn)顯示,D-D與FIB的最佳截點(diǎn)值分別為1.24mg/L、3.24g/L。單因素分析顯示,D-D≥1.24mg/L、FIB≥3.24g/L、NIH危險(xiǎn)度分級(jí)中高危、腫瘤直徑5cm及胃以外部位腫瘤均與GIST患者術(shù)后3、5年RFS降低有關(guān)(均P0.05);多因素分析顯示,D-D(RR=0.382,95%CI=0.151~0.967,P=0.042)、FIB(RR=0.123,95%CI=0.035~0.430,P=0.001)、腫瘤NIH危險(xiǎn)度分級(jí)(RR=0.149,95%CI=0.042~0.524,P=0.003)是影響GIST患者術(shù)后預(yù)后的獨(dú)立危險(xiǎn)因素。GIST患者NIH危險(xiǎn)度分級(jí)與D-D、FIB之間均存在明顯相關(guān)性(r=0.648、0.868,均P0.01)。結(jié)論:術(shù)前血漿D-D及FIB可作為預(yù)測(cè)GIST患者術(shù)后預(yù)后的參考指標(biāo)。
[Abstract]:Objective: to evaluate the prognostic value of preoperative plasma D-D and fibrinogen levels in patients with gastrointestinal stromal tumor (GIST). Methods: the clinicopathological and follow-up data of 170 patients with GIST from January 2010 to December 2015 were collected. Results among 170 patients with GIST, 91 were male and 79 were female. The primary site of the tumor was the most common in 122 cases of gastric carcinoma (71.8%), followed by small intestine in 34 cases (20.0%). The 3- and 5-year recurrence free survival rate of the whole group was 855.The ROC curve with survival outcome (metastasis or recurrence) as the state variable showed that D-D and FIB were the best. Single factor analysis showed that D-D 鈮，

本文編號(hào)：1523559