本文關(guān)鍵詞： 激光 放射治療 Meta分析 喉腫瘤　出處：《臨床耳鼻咽喉頭頸外科雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的:通過(guò)Meta分析T1a聲門型喉癌經(jīng)激光手術(shù)和放射治療后的保喉率、局部控制率、總生存率以及疾病特異性生存率。方法:檢索醫(yī)學(xué)數(shù)據(jù)庫(kù):PubMed、Web of Science、Embase數(shù)據(jù)庫(kù)、Cochrane、中國(guó)生物文獻(xiàn)數(shù)據(jù)庫(kù)(CBM)、相關(guān)期刊論文(CNKI)、萬(wàn)方數(shù)字期刊全文數(shù)據(jù)庫(kù)等,檢索時(shí)限均為建庫(kù)到2016年10月。由2位共同作者同時(shí)對(duì)搜索的相關(guān)文獻(xiàn)進(jìn)行閱讀、篩選以及文獻(xiàn)質(zhì)量評(píng)價(jià),從中提取與研究目的相關(guān)的詳細(xì)數(shù)據(jù),然后對(duì)提取的數(shù)據(jù)采用Review Manager 5.3軟件進(jìn)行Meta分析。結(jié)果:共納入符合要求的文獻(xiàn)12篇,總共1 530名研究對(duì)象。Meta分析結(jié)果表明,在對(duì)T1a聲門型喉癌經(jīng)激光手術(shù)和放射治療后,在保喉率(OR=3.23,95%CI=1.21~8.60,P=0.02)方面,放療要優(yōu)于激光手術(shù),在局部控制率、總生存率以及特異性疾病生存率方面未見明顯統(tǒng)計(jì)學(xué)差異。結(jié)論:在對(duì)T1a聲門型喉癌患者治療中,放療在保喉率方面優(yōu)于激光手術(shù),局部控制率、總生存率以及特異性疾病生存率未見明顯差異。
[Abstract]:Objective: to analyze the laryngeal preservation rate and local control rate of T1a glottic carcinoma after laser surgery and radiotherapy by Meta. Methods: the general survival rate and disease-specific survival rate were analyzed. Methods: the medical database: the Web of Science of Science Embase database was searched. China Biological Literature Database (CBM), China Journal Full-text Database (CNKI), Wanfang Digital Journal Full-text Database, etc. The time limit of retrieval is from the establishment of the database to October 2016. The two co-authors simultaneously read, screen and evaluate the relevant documents searched, and extract the detailed data related to the purpose of the research. Then the extracted data were analyzed by Meta with Review Manager 5.3 software. Results: 12 papers were included. Meta-analysis of a total of 1 530 subjects showed that after laser surgery and radiotherapy for T1a glottic laryngocarcinoma, the laryngeal preservation rate was 3.23. 95 CI1. 21 ~ 8. 60% P0. 02) radiotherapy is better than laser surgery in local control rate. There was no significant difference in the overall survival rate and the survival rate of specific diseases. Conclusion: in the treatment of T1a glottic carcinoma, radiotherapy is superior to laser surgery in laryngeal preservation rate and local control rate. There was no significant difference in overall survival rate and specific disease survival rate.
【作者單位】： 南昌大學(xué)第二附屬醫(yī)院耳鼻咽喉頭頸外科;南昌大學(xué)第二附屬醫(yī)院麻醉科;
【分類號(hào)】：R739.65
【正文快照】： 1南昌大學(xué)第二附屬醫(yī)院耳鼻咽喉頭頸外科(南昌,330006)2南昌大學(xué)第二附屬醫(yī)院麻醉科臨床上,聲門型喉癌是最常見的一種喉癌[1-3]。其中,T1a聲門型喉癌屬于早期喉癌的一種,�？蓡我坏赝ㄟ^(guò)激光手術(shù)治療或放射治療,且2種均應(yīng)用廣泛[2-5]。隨著先進(jìn)的激光手術(shù)的開創(chuàng),開放手術(shù)被逐漸

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本文編號(hào)：1471358