本文關(guān)鍵詞：中年肺癌與老年肺癌臨床特點(diǎn)對(duì)比研究　出處：《延安大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 肺癌 中年 老年 臨床特點(diǎn)

【摘要】：目的:通過(guò)對(duì)2010年12月-2014年1月延安大學(xué)附屬醫(yī)院住院確診的中年肺癌和老年肺癌患者相關(guān)臨床資料進(jìn)行回顧性分析,經(jīng)統(tǒng)計(jì)學(xué)處理,探討中、老年肺癌的臨床特點(diǎn),期望為肺癌的早期臨床診斷提供幫助。方法:(1)調(diào)取2010年12月-2014年1月在延安大學(xué)附屬醫(yī)院住院并且經(jīng)細(xì)胞學(xué)或病理學(xué)確診的中年以上肺癌患者260例,其中中年組(45-59歲)128例(49.23%);老年組(60歲以上)132例(50.77%)。(2)回顧性分析所選患者的臨床資料:包括性別、吸煙指數(shù)、首發(fā)臨床表現(xiàn)、胸部CT表現(xiàn),組織學(xué)類型以及臨床分期。(3)采用SPASS19.0統(tǒng)計(jì)軟件處理上述資料,計(jì)數(shù)資料用卡方檢驗(yàn),以P0.05為差異有統(tǒng)計(jì)學(xué)意義。結(jié)果:1.性別分布中年組:男82例(64.1%),女46例(35.9%);老年組:男94例(72.7%),女36例(27.3%),兩者性別分布無(wú)顯著性差異(p0.05),均以男性多見。2.吸煙指數(shù)中年組肺癌患者中吸煙指數(shù)"g400,62例(48.4%)、老年組肺癌患者中吸煙指數(shù)"g400,64例(48.5%),兩者吸煙指數(shù)比較無(wú)顯著性差異(p0.05),但均有較高吸煙史。3.臨床表現(xiàn)中年組臨床表現(xiàn):咳嗽95例(74.2%)、氣短52例(40.6%)、胸痛34例(26.6%)、其他14例(10.9%)、咯血8例(6.3%)、無(wú)癥狀1例(0.7%);老年組臨床表現(xiàn):咳嗽86例(65.2%)、氣短42例(31.8%)、胸痛20例(15.2%)、其他22例(16.7%)、咯血10例(7.6%)、無(wú)癥狀2例(1.5%);兩者臨床表現(xiàn)無(wú)顯著性差異。4.病理類型中年組:小細(xì)胞癌26例(20.60%)、腺癌50例(39.10%)、鱗癌46例(36.10%)、其他6例(4.2%);老年組:小細(xì)胞癌26例(19.40%)、腺癌40例(30.20%)、鱗癌50例(38.10%)、其他16例(12.30%)。兩者病理類型分別比較無(wú)顯著差異(p0.05),均以腺癌、鱗癌高發(fā)。5.臨床分期(NSCLC)方面:中年組Ⅰ~Ⅲa期54例(64.2%),Ⅲb~Ⅳ期30例(35.71%);老年組肺癌患者Ⅰ~Ⅲa期46例(51.11%),Ⅲb~Ⅳ期44例(48.89%),兩組患者臨床分期經(jīng)統(tǒng)計(jì)學(xué)比較,無(wú)顯著性差異(p0.05)。6.中年組胸部CT表現(xiàn):周圍型40例(31.3%),中央型88例(68.7%);老年組胸部CT表現(xiàn):周圍型14例(10.67%),中央型118例(89.4%),經(jīng)統(tǒng)計(jì)學(xué)分析,兩組胸部CT表現(xiàn)有顯著性差異,即中年組周圍型肺癌發(fā)病率較老年組高,但二者均以中央型肺癌高發(fā)(p0.05)。結(jié)論:該項(xiàng)研究結(jié)果表明,中、老年肺癌在性別分布、吸煙指數(shù)、首發(fā)臨床表現(xiàn)、病理分型、臨床分期(非小細(xì)胞肺癌)等方面無(wú)顯著性差異;僅在胸部CT表現(xiàn)方面,二者有顯著性差異,即中年肺癌患者“周圍型”肺癌發(fā)生率較老年更多見,但二者均以中央型肺癌為主。
[Abstract]:Objective: to middle-aged elderly patients with lung cancer lung cancer and related clinical data of December 2010 -2014 year in January in Affiliated Hospital of Yan'an University were analyzed retrospectively, after statistical treatment, to investigate the clinical characteristics of elderly patients with lung cancer, early diagnosis of lung cancer, expected to provide help. Methods: (1) 260 cases of middle-aged and above lung cancer diagnosed in Affiliated Hospital of Yan'an University in December 2010 January and diagnosed by cytology or pathology in January -2014 were enrolled. 128 cases (49.23%) were middle-aged group (45-59 years old), 132 cases (50.77%) were in the elderly group (60 years old or above). (2) retrospective analysis of the clinical data of selected patients, including sex, smoking index, first clinical manifestation, chest CT, histological type and clinical staging. (3) the SPASS19.0 statistical software was used to deal with the above data, and the counting data were checked with chi square, and the difference was statistically significant with the difference of P0.05. Results: 1., gender distribution in middle-aged group: 82 men (64.1%), 46 women (35.9%), the elderly group: 94 men (72.7%), 36 women (27.3%), there was no significant difference in gender distribution between them (P0.05), most of them were male. 2. smoking index in the middle-aged group, the smoking index in the lung cancer patients was g400,62 cases (48.4%), and the smoking index in the elderly group patients g400,64 (48.5%). There was no significant difference in the smoking index between the two groups (P0.05), but they all had a higher smoking history. 3. clinical manifestations of middle-aged group clinical manifestations: 95 cases of cough, shortness of breath (74.2%) of 52 cases (40.6%), 34 cases of chest pain (26.6%), the other 14 cases (10.9%), 8 cases of hemoptysis (6.3%), 1 cases without symptoms (0.7%); the clinical features of the aged group: 86 cases of cough, shortness of breath (65.2%) 42 cases (31.8%), 20 cases of chest pain (15.2%), the other 22 cases (16.7%), 10 cases of hemoptysis (7.6%), 2 cases without symptoms (1.5%); there was no significant difference of clinical manifestations. 4., pathological type of middle-aged group: small cell carcinoma in 26 cases (20.60%), adenocarcinoma in 50 cases (39.10%), squamous cell carcinoma in 46 cases (36.10%), and other 6 cases (4.2%); the elderly group: small cell carcinoma 26 cases (19.40%), adenocarcinoma 19.40% cases (19.40%), squamous cell carcinoma cases, and other cases. There was no significant difference in the pathological types of the two (P0.05), with high incidence of adenocarcinoma and squamous cell carcinoma. 5. clinical stage (NSCLC): middle age group I, III, a stage 54 cases (64.2%), stage III b~ IV stage 30 cases (35.71%); elderly group lung cancer patients with stage I III a stage 46 cases (51.11%), stage III b~ IV stage 44 cases (48.89%), two group patients clinical staging by statistical comparison, no significant difference (P0.05). 6. middle-aged group: chest CT manifestations of 40 cases were peripheral type (31.3%), 88 cases of central type (68.7%); the elderly group: chest CT manifestations of 14 cases were peripheral type (10.67%), 118 cases of central type (89.4%), by statistical analysis, two groups of chest CT showed significant differences, the middle age group around the onset lung cancer rate was higher than old age group, but the two are in central lung cancer (P0.05). Conclusion: the results of this study suggest that, in elderly patients with lung cancer in the clinical distribution of sex, smoking index, the first manifestation, pathological type, clinical stage (NSCLC) no significant differences; only in the chest CT findings, there was significant difference between the two, namely "peripheral" middle aged patients with lung cancer the incidence rate of lung cancer is more common in the elderly, but the two are mainly to central lung cancer.
【學(xué)位授予單位】：延安大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R734.2

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本文編號(hào)：1341501